Tumor outcomes (progression, response to immunotherapies) are influenced by tumor-intrinsic and the tumor-immune microenvironment (TiME) factors. To overcome existing limitations of phenotyping tumors using single-time, single-siteex vivo biopsies in predicting tumor behavior, we propose an integrated dynamic approach for TiME combining inflammation, vasculature/ angiogenesis features through h...

background: squamous cell carcinoma (scc) is the most common malignancy in oral cavity. angiogenesis is essential for the development and progression of scc. recently, some studies have reported that mast cells may play a role in tumor progression via promoting angiognesis. since the results of various studies on the role of mast cells in tumor progression is not uniform, the aim of this study ...

background: angiogenesis, the formation of new blood vessels from preexisting ones, is one of the most important physiological and pathological processes occur in the body. in the pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is crucially required for the devolopment of the disease. zataria multiflora as a member of la...

Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...

objective(s): the goal of this study was assessing the prophylactic effect of exercise and its role as an adjuvant therapy on level of cytokines involved in angiogenesis in estrogen-dependent breast cancer. materials and methods: forty female balb/c mice were randomly assigned to exercise-tumor-exercise (ete), exercise-tumor-rest (etr), rest-tumor-exercise (rte) and rest-tumor-rest (rtr) groups...

Autophagy, the major lysosomal pathway for degradation and recycling of cytoplasmic materials, is increasingly recognized as a player in endothelial cell (EC) biology vascular pathology. Particularly solid tumors, tumor microenvironmental stress such hypoxia, nutrient deprivation, inflammatory mediators, metabolic aberrations stimulates autophagy tumor-associated blood vessels. Increased ECs ma...

background : angiogenesis, the formation of new blood vessels from preexisting ones, is among the most important physiological and pathological processes that occur in the body. under pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is substantial for the development of the disease. zataria multiflora is a member of the l...

Background/Aim: The tumor microenvironment plays an important role in progression. Tumor-associated macrophages (TAMs) have been reported to promote proliferation, invasion, metastasis, angiogenesis, and immunosuppression. Furthermore, angiogenesis has induce chemoresistance due the inefficient distribution of drugs cancer cells. However, impact TAMs on via colorectal (CRC) remains unclear. aim...

Approved angiogenesis inhibitors generally target certain growth factors or their receptors, which exist in both normal and cancerous cells; this results suppression of cell-signaling pathways throughout the body causes adverse effects. For reason, there is a need for new inhibitor that can specifically tumor vasculature. In our previous study, we revealed doppel, prion-like protein, was overex...