Various mushrooms have been used as folk medicine for long times, the higher Basidiomycetes have become a matter of great interest due to their diverse nutritional, medicinal, and pharmacological properties. 650 species and intraspecific taxa from 182 genera of higher Hetero- and Homo-basidiomycetes have been listed that contain biological active anti-tumor and immunostimulative polysaccharides...

Various mushrooms have been used as folk medicine for long times, the higher Basidiomycetes have become a matter of great interest due to their diverse nutritional, medicinal, and pharmacological properties. 650 species and intraspecific taxa from 182 genera of higher Hetero- and Homo-basidiomycetes have been listed that contain biological active anti-tumor and immunostimulative polysaccharides...

Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel structural adaptation are used to explore the hypothesis that abnormal adaptive responses to local hemodynamic and metabolic stimuli contribute to aberrant morphological and hemodynam...

brown tumors may occur secondary to hyperparathyroidism in patients with chronic renal failure (ckd). they are increasingly rare because hyperparathyroidism in now diagnosed and treated at an early stage. we report 67-year-old man who had been on hemodialysis for crf for over 3 years, who presented with back pain over the thoracolumbar junction from 2 years ago and because of pain he could not ...

background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...

INTRODUCTION Recent studies indicated tumors may be comprised of heterogeneous molecular subtypes and incongruent molecular portraits may emerge if different areas of the tumor are sampled. This study explored the impact of intra-tumoral heterogeneity in terms of activation/phosphorylation of FDA approved drug targets and downstream kinase substrates. MATERIAL AND METHODS Two independent sets...

Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in cancer patients. Even cancers driven by single mutated oncogene, variability response to targeted therapies well known. The existence additional genomic alterations among tumor cells can only partially explain this variability. As such, nongenetic factors are increasingly seen as critical contributors relapse...

introduction: a keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. it represents 2–11% of jaw cysts, and has a slow but aggressive growth. the evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesion...

conclusions pnet/ews should be included in the differential diagnosis of renal tumors in symptomatic young adults. patients with localised pnet/ews treated with a combination of surgery and chemotherapy have an excellent chance of long-term survival, as in the case we have presented. introduction primitive neuroectodermal tumor (pnet)/ewing’s sarcoma (ews) belongs to a family of neoplasms that ...