BACKGROUND AND AIM Evidence-based clinical guidelines on Ulcerative colitis (UC) have been developed through a consensus, while GRADE methodology is the current standard for guideline development. This is the first one based on GRADE methodology on UC. METHODS Following GRADE methodology, the Spanish Group of Ulcerative Colitis and Crohn's disease (GETECCU) have developed a guideline on UC tr...

In a search for Helicobacter species in the intestinal mucosae of 42 patients with ulcerative colitis (UC) and 74 without UC, only H. pylori was found. Although the bacterium was detected in UC patients by culture (7.1%) and nested PCR (19.0%), its presence was not associated with the disease (P = 0.13).

Arterial stroke is a rare complication of Ulcerative Colitis (UC) and so far there are no guidelines for the treatment of stroke in these patients. The pathogenesis of thrombosis in UC remains uncertain. This case is one of the few published reports on the relationship between stroke associated with UC and the factor V Leiden mutation.

Cytomegalovirus (CMV) is a genus in the family Herpesviridae that has been associated with gastrointestinal syndromes. In this work we looked for a possible association of CMV infection with colorectal cancer and ulcerative colitis (UC). Blood and enteric tissue samples of 14 patients with colorectal cancer and of 21 with UC were subjected to a nested-PCR that amplifies part of the gB gene of C...

BACKGROUND To explore correlation between clinical and endoscopic indices in inflammatory bowel disease (IBD) patients. SUBJECTS AND METHODS There were 112 patients with inflammatory bowel disease. All patients with diagnosed IBD was established a degree of clinical and endoscopic disease activity. CDAI (Crohn's disease activity index) was used as clinical and SES-CD (Simplified Endoscopic Cr...

Ulcerative colitis (UC) is a wide-reaching health problem with unknown etiology and its high mortality rates. Conventional therapy for onset treatment of active UC includes immunomodulators, corticosteroids, purine analogues, antibiotics and 5-aminosalicylic acid. Unfortunately, after giving long term treatment to the patients associated with UC, these drugs are found to have undue side effects...

the association of hla class ii genes with ulcerative colitis (uc) as an autoimmune disease has been investigated for several years. however, factors responsible for genetic predisposition of this disease have so far not been clearly understood. in this study, for the first time, we aimed to investigate the association between hla-drb1 types and uc in the population of kerman, a city southeast ...

BACKGROUND Hyperbaric oxygen therapy (HBOT) provides 100% oxygen under pressure, which increases tissue oxygen levels, relieves hypoxia and alters inflammatory pathways. Although there is experience using HBOT in Crohn's disease and ulcerative colitis, the safety and overall efficacy of HBOT in inflammatory bowel disease (IBD) is unknown. AIM To quantify the safety and efficacy of HBOT for Cr...

the aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. the plasma concentrations of the four flavonoids were determined ...