As genotyping and genetic testing become more sophisticated, accessible, and costeffective, these tools hold great promise for predicting and improving responses to medications.

We evaluated the effect of tigecycline (50-mg and 200-mg doses) on corrected QT (QTc) intervals and assessed safety and tolerability in a randomized, placebo-controlled, four-period crossover study of 48 (44 male) healthy volunteers aged 22 to 53 years. Fed subjects received tigecycline (50 mg or 200 mg) or placebo in a blinded fashion or an open-label oral dose of moxifloxacin (400 mg) after 1...

Am 24./25.11.2011 trafen sich mehr als 50 Teilnehmer/innen zum Jahrestreffen der Fachgruppe Requirements Engineering, dieses Mal in Hamburg. Uns empfing die Blohm + Voss Naval GmbH in ihren großzügigen Räumen mit ausgezeichneter Verpflegung. Wir bedanken uns ganz herzlich bei Herr Grudda und Frau Maas, die das Treffen so erfolgreich und freundlich vorbereitet und betreut haben. Das Treffen bega...

In diesem Beitrag wird der Literacyoder Grundbildungsbegriff der PISAStudie auf die Informatik übertragen. Dazu wird eine Unterscheidung in Kompetenzklassen eingeführt, die Arten informatischer Tätigkeit beschreiben. Anhand von Beispiel-Testitems werden diese Kompetenzklassen operationalisiert. 1 Informatik und PISA In jüngster Zeit hat nichts die Bildungslandschaft so sehr aufgerüttelt wie die...

This paper presents the principles of a Constraint Logic Program debug-ging module, currently implemented in the DiSCiPl project 3], which concerns performance debuggging and helps to understand program behaviour in particular in complex combinatorial problems. It is based on search-tree abstractions. It deenes the notion of abstract search-tree and a method to specify it. The originality of th...

f~bstract— Schemes based on the tagging of packets have recently been proposed as a low-cost way to augment the single class best effort service model of the current Internet by including some kind of service discrimination. Such schemes have a number of attractive feat m-es, however, it is not clear exactly what kind of service they would provide to applications. Yet quantifying such service i...

PURPOSE To test the effect of insulin treatment on the pharmacokinetics of metformin in rats with diabetes mellitus induced by alloxan (DMIA rats). The following results were reported from other studies. Metformin was metabolized via hepatic CYP2C11, 2D1, and 3A1/2 in rats. In DMIA rats, the protein expression and mRNA levels of hepatic CYP2C11 and 3A1/2 decreased and increased, respectively. I...

Introduction: Hearing impairment is a complex medical disorder whichhas genetic and non-genetic causes. Gap Junction Protein Beta 2 (GJB2) gene variant is a well-known disease-causing gene among patients with hearing impairment. The frequencies of genetic variants in the GJB2 gene are different in each population. This study aimed to discuss the GJB2 gene status in an Iranian population with he...

Background and Objective: One of the main reasons for the ongoing pandemic is the substitutions in the Receptor binding domain(RBD), which is involved in binding to the ACE2 receptor. Methods: Oro-nasopharyngeal swabs were collected from 41 confirmed patients between September 2020 and May 2021 to analyze the mutations of SARS-CoV-2 RBD in Khuzestan Province. Bi-Directional sequencing was use...

viroids are smallest, single-stranded, circular, highly structured plant pathogenic rnas that do not code for any protein. viroids belong to two families, the avsunviroidae and the pospiviroidae. members of the pospiviroidae family adopt a rod-like secondary structure. in this study the most stable secondary structures of citrus viroid variants that reported from fars province were drawn. the m...