OBJECTIVES To compare the efficacy and tolerability of agnus castus fruit (Vitex agnus castus L extract Ze 440) with placebo for women with the premenstrual syndrome. DESIGN Randomised, double blind, placebo controlled, parallel group comparison over three menstrual cycles. SETTING General medicine community clinics. PARTICIPANTS 178 women were screened and 170 were evaluated (active 86; ...

Vitex agnus-castus (VAC) is a plant that has recently been used to treat the symptoms of menopause, by its actions on the central nervous system. However, little is known about its actions on disturbances in lipid metabolism and nonalcoholic fat liver disease (NAFLD), frequently associated with menopause. Ovariectomized (OVX) rats exhibit increased adiposity and NAFLD 13 weeks after ovary remov...

Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating women's health.Eight databases were searched us...

According to their accessibility and lower cost-effectiveness when compared synthetic chemical treatments, medicinal wild plants herbs have been used for ages as beneficial tools in the management of many diseases. The popular plant Vitex agnus-castus, which is indigenous Mediterranean region widely distributed Europe, Asia, North Africa, treat a number conditions diseases, including premenstru...

This study was conducted to determine the Protective effect of aqueous extracts Vitex agnus castus plant both doses, Normal active does(50mg/kg) and double (100mg/kg) in liver enzymes comported deferent it between male female’s Mice, that exposed oxidative stress induced by hydrogen peroxide (0.5%) with drinking water for (30) days, there were distributed into 10 groups which are (control group...

objective(s) there is well documented evidence for the increase in widespread use of complementary and alternative medicine in the treatment of physical and psychiatric symptoms and disorders within the populations. in the present study, we investigated the influence of vitex agnus-castus (vitex) on anxiety-like behaviors of rats. materials and methods elevated plus maze which is one of the met...

Introduction: PCOS is an important reproductive and endocrine disorder in women in the reproductive age. Present reports indicate that Vitex agnus-castus acts through hypothalamus-pituitary axis. This study was carried out to evaluate the effects of Vitex fruit hydroalcoholic extract on the alteration of sex hormones in a PCOS animal model. Methods: Following 14 days of monitoring of estrous...

Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg...

Retinal pathologic angiogenesis is the leading cause of blindness in human generate from age-relatedmacular degeneration (AMD), diabetic retinopathy and premature (ROP).The aim this studyis to investigate effect vitex agnus castus leave extract on induced retinal rabbitsby intravitreal injection VEGF. Alcoholic prepared formulated forintravitreal injection. Twenty four pigmented rabbits include...

A multicentric noninterventional trial (open study without control) to investigate the efficacy and tolerance of a drug in a large number of patients under routine medical conditions was performed for a new solid preparation from an extract of the fruit of Vitex agnus castus (VAC, Vitex, chaste tree, Chasteberry) in 1634 patients suffering from premenstrual syndrome (PMS). A specific questionna...