The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. These rate-, rhythm- and voltage-dependent effects were accurately predicted by the proposed model. The model was also able to predict seve...

We obtain revenue guarantees for the simple pricing mechanism of a single posted price, in terms of a natural parameter of the distribution of buyers’ valuations. Our revenue guarantee applies to the single item n buyers setting, with values drawn from an arbitrary joint distribution. Specifically, we show that a single price drawn from the distribution of the maximum valuation Vmax = max{V1, V...

We study discretisation effects in cellular automata models for pedestrian dynamics by reducing the cell size. Then a particle occupies more than one cell which leads to subtle effects in the dynamics, e.g. non-local conflict situations. Results from computer simulations of the floor field model are compared with empirical findings. Furthermore the influence of increasing the maximal walking sp...

The kinetics and regulation of D-xylose uptake were investigated in the efficient pentose fermentor Candida succiphila, and in Kluyveromyces marxianus, which assimilate but do not ferment pentose sugars. Active high affinity (Km approximately 3.8 mM; Vmax approximately 15 nmol/[mg min]) and putative facilitated diffusion low-affinity (Km approximately 140 mM; Vmax approximately 130 nmol/[mg min...

1. The electrophysiological effects of CI-980, a new tubulin-binding agent that inhibits assembly of cytoplasmic microtubules, on transmembrane action potential characteristics were studied in right ventricular papillary muscles from guinea-pig hearts. 2. In papillary muscles driven at 1 Hz, CI-980 at concentrations > or = 10(-5) M produced a concentration-dependent increase in the maximum upst...

Ventricular function was evaluated in 18 patients prior to left ventriculography and selective coronary arteriography. Simultaneous left ventricular pressure (catheter-tip manometer) and dP/dt were recorded at resting heart rates and during tachycardia induced by right atrial pacing. Pressure-velocity curves were constructed from which Vmax and maximum measured contractile element velocity (max...

Çalışmada, toprağın katalaz enziminin kinetik parametrelerini (Vmax, KM, Vmax/KM, KSEE, [S]opt ve υ0,max) hesaplamak için H2O2 substratının farklı konsantrasyonlarında (3, 6, 9, 12, 15, 18, 21, 24, 30 %) analizler yapılmıştır. Bu parametrelerin hesaplanması analiz sonuçları kullanılarak önce hız (υ) değerleri hesaplanmıştır. Sonra ürün – substrat: [P]=f([S]) bağıntısını ifade eden modeller beli...

The pattern of L-alanine uptake in isolated cells of interscapular brown adipose tissue has been determined. The uptake can be divided into the diffusion component (Kd = 0.55 min-1) and a saturable Na(+)-dependent transport (KM = 0.87 mM and Vmax = 155 nmol/min/10(6) cells). The saturable component can be subdivided into MeAIB-sensitive (KM = 1.63 mM and Vmax = 162 nmol/min/10(6) cells) and MeA...

Ventricular function was evaluated in 18 patients prior to left ventriculography and selective coronary arteriography. Simultaneous left ventricular pressure (catheter-tip manometer) and dP/dt were recorded at resting heart rates and during tachycardia induced by right atrial pacing. Pressure-velocity curves were constructed from which Vmax and maximum measured contractile element velocity (max...

lopt was set based on scaled nominal values of all muscle-tendon parameters for an average adult male from literature [1]. Scaling algorithm from SIMM was followed. Since the Gastrocnemius muscle was modeled as an effective representation of the two heads, all parameters set were for the bigger, more pennate medial head. Maximal muscle contraction vmax values for all subjects were set as in [2]...