One-pot combinations of sequential catalytic reactions can offer practical and ecological advantages over classical multi-step synthesis schemes. In this context, the integration of enzymatic and chemo-catalytic transformations holds particular potential for efficient and selective reaction sequences that would not be possible using either method alone. Here we report the one-pot combination of...

Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to gene...

[bmim][OTf] can promote regio- and chemo-selective glycosylation reactions at room temperature. Furthermore, the applicability to ambient three-component reactivity-based one-pot glycosylation reactions is demonstrated for the synthesis of several trisaccharides.

THE TELESCOPIC APPROACH AS A TOOL FOR GREEN CHEMISTRY. One-pot reactions have become a powerful tool for the development of sustainable protocols in organic synthesis. In particular, telescoping multi-step reactions, i.e., execution sequential without isolating and purifying intermediates, reduces number steps while preventing waste generation. Additionally, processes more through time, reagent...

A one-pot reaction sequence is described in which the addition of one compound allowed switching between simultaneously occurring oxidation and reduction reactions.