نتایج جستجو برای: wrap53
تعداد نتایج: 72 فیلتر نتایج به سال:
We report here that Hap1p (originally named Cyp1p) has an essential function in anaerobic or heme-deficient growth. Analysis of intragenic revertants shows that this function depends on the amino acid preceding the first cysteine residue of the DNA-binding domain of Hap1p. Selection of recessive extragenic suppressors of a hap1-hem1- strain allowed the identification, cloning, and molecular ana...
The expression of microRNA-223 (miR-233) has been investigated in various types of cancer. However, to the best of our knowledge, the expression and function of miR-223 in acute myeloid leukemia (AML) remains to be elucidated. The expression of miR-223 was measured by reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-223, cell viability assays, cell a...
A wetting and drying scheme (WDS) is developed to incorporate into a three-dimensional sigmacoordinate coastal ocean model (POM; Blumberg and Mellor, 1983) with proposing an extended logarithmic profile within and above bed boundary layers to accurately simulate 3D hydrodynamics in extremely shallow coastal seas. While the WDS is simplistically formulated, it can selectively retain the computat...
Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early-onset malignancies, and somatic mutations occur in 20-40% of all breast cancer cases. We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer. Single nucleotide polymorphisms (SNPs) identified in a re-sequence analysis...
Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4). It was not known if Swd2 is important for the function of either of these entities. We show here that, in extract from cells depleted of Swd2, cleavage and polyadenylat...
Telomerase Cajal body protein 1 (TCAB1) is a telomerase holoenzyme, which is markedly enriched in Cajal bodies (CBs) and facilitates the recruitment of telomerase to CBs in the S phase of the cell cycle. This recruitment is dependent on TCAB1 binding to a telomerase RNA component. The majority of cancer cells are able to grow indefinitely due to telomerase and its mechanism of trafficking to te...
The spliceosomal small nuclear RNAs (snRNAs) are modified post-transcriptionally by introduction of pseudouridines and 2'-O-methyl modifications, which are mediated by box H/ACA and box C/D guide RNAs, respectively. Because of their concentration in the nuclear Cajal body (CB), these guide RNAs are known as small CB-specific (sca) RNAs. In the cell, scaRNAs are associated with the WD-repeat pro...
از زمان کشف P53 در سال 1979 به عنوان یک آنتی ژن توموری تا به امروز که جایگاه آن در قالب یک ژن سرکوبگر توموری مهم تثبیت شده است بیش از شصت و چهار هزار مقاله و گزارش پژوهشی با نام این پروتئین، در PubMed منتشر شده است. هرچند نتایج این پژوهش ها به روشن شدن ساختار، عملکرد و تنظیم P53 کمک کردهاند با این حال باعث به وجود آمدن ابهام ها و پرسش های بیشتری پیرامون این پروتئین شدهاند. شناسایی ایزوفرم ه...
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