Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet antioxidants can neutralize these compounds. The apple is widely consumed, with several antioxidant activity compounds. The present study evaluated the effects of concentrated apple extract (CAE) in acetic acid induced colitis....

Commentary Childhood absence epilepsy (CAE) is a common pediatric epilepsy syndrome, accounting for approximately 10 to 17 percent of childhood epilepsy (1, 2). The EEG pattern in CAE is an approximate 3-Hz bilateral synchronous, symmetric spike and slow wave, with seizures often activated by hyperventila-tion (HV). Treatment of CAE is not optimal, with many children having incomplete seizure c...

Coronary artery ectasia (CAE) is characterized by inappropriate dilatation of the coronary vasculature. The mechanisms of CAE are not well known. Insulin-like growth factor-1 (IGF-1) may make endothelial cells and smooth muscle cells more sensitive to the effects of growth hormone. In the present study, we hypothesized that IGF-1 may have an impact on the formation of ectasia and aneurysm in ar...

BACKGROUND Whether coronary artery ectasia (CAE) is a unique clinical finding or results from other clinical entities is still unknown. We aimed to determine the CAE prevalence, investigate the relationship between CAE and patients' demographic and clinical characteristics, and assess the prognosis at follow-up in a sample of Iranian population. METHODS Totally, 10057 patients who underwent c...

Cerebral air embolism (CAE) is a common, often lethal, complication in blunt and penetrating chest trauma. The factors affecting the outcome of CAE patients are poorly understood, and there is no generally accepted treatment algorithm. In this report, we present the case of a 28-year-old male motorcyclist with a massive CAE, including bilateral internal carotid artery air on computed tomographi...

The present study aimed to investigate the effects of angiotensin (Ang) 1-7 on caerulein (CAE)-stimulated nuclear factor (NF)‑κB, Toll‑like receptor (TLR4) and cytokine expression using pancreatic acinar AR42J cells. AR42J cells were treated with 10 nmol/l CAE for various durations. In addition, cells were pretreated with various concentrations of Ang 1‑7 or A779, a specific antagonist of Ang 1...

Leaf extracts of C. vamana, endemic to Kerala state in India, were found to inhibit cell cycle progression in synchronous cultures of P. polycephalum in a concentration and phase-specific manner. Crude alkaloid extract (CAE) elicited maximum cell cycle delays in comparison to soxhletted chloroform, acetone and aqueous extracts. Total alkaloid content of CAE was found to be 64.9 mg/g. CAE showed...

Hypohydration occurs during cold-air exposure (CAE) through combined effects of reduced fluid intake and increased fluid losses. Because hypohydration is associated with reduced physical performance, strategies for maintaining hydration during CAE are important. Glycerol ingestion (GI) can induce hyperhydration in hot and temperate environments, resulting in greater fluid retention compared wit...

As HPC continues its aggressive platform migration from proprietary supercomputers and Unix servers to HPC clusters, expectations grow for clusters to meet the I/O demands of increasing fidelity in CAE modeling and data management in the CAE workflow. Cluster deployments have increased as organizations seek ways to costeffectively grow compute resources for CAE applications, and during this mig...

The urgent issues for automobile companies today are how to reduce the time and cost required for developing a new car. CAE ( Computer Aided Engineering ) has been regarded as an efficient way to solve these issues, and as a numerical experiment to replace prototypes and experiments. CAE was first introduced to reproduce phenomena that are elusive in regular experiments. Now it is even capable ...