Hypoxic-ischemic brain injury (HIBI) results in death or long-term neurologic impairment in both adults and children. In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI. MiR-132 dysregulation was induced prior to ...

Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. Previous studies have shown that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. However, the precise mechanisms of miR‑132 in osteosarcoma have not been well clarified. Real-time PCR was performed to d...

We study the problem of counting alternating permutations avoiding collections of permutation patterns including 132. We construct a bijection between the set Sn(132) of 132-avoiding permutations and the set A2n+1(132) of alternating, 132avoiding permutations. For every set p1, . . . , pk of patterns and certain related patterns q1, . . . , qk, our bijection restricts to a bijection between Sn(...

AIM HIV infection is associated with distortion of T-cell homeostasis and the IL-7/IL7R axis. Progressive infection results in loss of CD127+132- and gains in CD127-132+ CD4+ and CD8+ T-cells. We investigated the correlates of loss of CD127 from the T-cell surface to understand mechanisms underlying this homeostatic dysregulation. METHODS Peripheral and cord blood mononuclear cells (PBMCs; CB...

Dysregulation of microRNA-132 (miR-132) has been observed in various types of human cancers. We investigated the biological functions and associated molecular mechanisms of miR-132 activity in human osteosarcoma tissues and cells. miR-132 expression was measured in human osteosarcoma tissues by quantitative real-time polymerase chain reaction. miR-132 mimics, inhibitors, and negative controls w...