Introdution: Obesity is a systemic disorder that disruption the regulation of the effective proteins; in fat metabolism (Desnurtin, FNDC5 it leads to resistance to insulin and Diabetes.  The aim of this study was comparing the 6 weeks of high-intensity interval and continuous training with standard diet on desnutrin and FNDC5 genes expression in subcutaneous adipose tissue and the quadrice...

We are experiencing a worldwide epidemic of obesity and type II diabetes. Our group has been interested in the development of both white and brown fat, particularly at the level of gene transcription. PGC1a was first described as a coactivator of PPARg in the control of brown fatmediated thermogenesis. More recent work has shown that PGC1a controls much of an exercise program in skeletal muscle...

PURPOSE Acute hypobaric hypoxia (HH) causes persistent cognitive impairment, affecting memory function specifically. Mitochondrial dysfunction and synaptic morphological change were the prominent pathological features of HH exposure on brain. Quercetin, a flavonoid found in fruits, vegetables, leaves and grains, is reported to prevent ischemia induced by neuronal injury. This study investigated...

Obesity and its associated comorbidities such as type 2 diabetes cardiovascular diseases are – despite all the current efforts in research still difficult to tackle therapeutically. For people struggling with body weight, diet physical activity can have profound beneficial effects. The main benefit of exercise is rendering a negative energy balance by skeletal muscle usage carbohydrates lipids....