The novel benzoindane S 18126 possessed > 100-fold higher affinity at cloned, human (h) D4 (Ki = 2.4 nM) vs. hD2 (738 nM), hD3 (2840 nM), hD1 (> 3000 nM) and hD5 (> 3000 nM) receptors and about 50 other sites, except sigma1 receptors (1.6 nM). L 745,870 similarly showed selectivity for hD4 (2.5 nM) vs. hD2 (905 nM) and hD3 (> 3000 nM) receptors. In contrast, raclopride displayed low affinity at...

Allium Jesdianum (AJ) is the native plant mostly grown in Middle East region that has the excellent pharmacological properties. In this study, we evaluated the hepatoprotective effect of hydroalcoholic extract of AJ on liver injury induced by Bromobenzene (BB) in male mice. Animals were randomly divided into five groups, control group received normal saline plus olive oil, groups 2-4 received(5...

synthetic lhrha or its superactive analogues stimulate gth release. it shows an overlap in the biological activity of lhrha and gnrh in many teleost species. the aim of the present study was to investigate the effects of lhrha2, metoclopramide and chlorpromazine on hpg axis and plasma levels of ght ii. luteinizing hormone releasing hormone analogue 2 (lhrha2) (3 mg/kg) with dopamine antagonis’s...

The objective of this study was to evaluate effects of zinc oxide nanoparticles (nano-ZnOs) as a substitute for colistin sulfate (CS) and/or zinc oxide (ZnO) on growth performance, serum enzymes, zinc deposition, intestinal morphology and epithelial barrier in weaned piglets. A total of 216 crossbred Duroc×(Landrace×Yorkshire) piglets weaned at 23 days were randomly assigned into 3 groups, whic...

The ability of celecoxib and alpha-difluoromethylornithine (DFMO) to modulate the DNA hypomethylation and the hypermethylation of the estrogen receptor (ER)-alpha gene in colon tumors was evaluated as potential biomarkers for chemoprevention. Colon tumors were induced in rats by azoxymethane. Celecoxib (500 mg/kg), DFMO (100, 1000 and 3000 mg/kg) or celecoxib + 1000 mg/kg DFMO were administered...

The increasing use of plant-based medicines necessitates safety evaluations all medicinal plants. This study evaluated the effects mango (Mangifera indica) leaf extracts on albino rats (Rattus norvegicus). phytochemistry plant’s extract was evaluated, followed by a determination its acute toxicity using 24 rats. Thereafter, chronic determined another set rats, separated into four groups six eac...

Pelargonium odoratissimum is a perennial evergreen used as a fragrant ornamental plant. Leaves, green branches and fresh flowers contain essential oils, that have been shown to possess antibacterial, antifungal, antiviral, insecticidal and antioxidant properties. In order to study the effect of foliar spray of ZnSO4 (0, 1000, 2000, 3000 and 4000 mg L-1) on vegetative growth and some physiologic...

Lead in house dust has long been recognized as a principal source of excess lead absorption among children at the Bunker Hill Superfund Site (BHSS) in northern Idaho. House dust lead concentration from homeowner's vacuum cleaner bags has been monitored since the epidemic of childhood lead poisoning in 1974. Geometric mean house dust lead concentrations decreased from >10000 mg/kg in 1974 to app...