BACKGROUND This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. METHODS Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed...

BACKGROUND Previous research has linked genomic variations of the oxytocin receptor (OXTR) gene with individual differences in empathy. The impact of these variations on specific cognitive and emotional aspects of empathy, however, remains to be clarified. METHODS We analysed associations of a common OXTR polymorphism (rs53576) with trait empathy in a sample of 421 blood donors (231 M, 190 F;...

Abstract Background The adrenergic system plays a central role during the clinical course of hypertrophic cardiomyopathy (HCM) and hence beta-blocker therapy is first-line treatment option according to current guidelines. Previous studies demonstrated variable cellular response an stimulus due adrenoceptor-1 (ADRB-1) gene polymorphism in several patient groups including hypertension dilated car...

A functional single nucleotide polymorphism (SNP) of the PTPN22 gene encoding a protein tyrosine phosphatase has been associated with autoimmune disorders including myasthenia gravis (MG). As the PTPN22 R620W polymorphism has a wide variation of allele frequencies among different populations, this polymorphism was investigated in MG in Turkey. An emphasis is put on MG subgroups according to aut...

Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in th...

Background & Aims: Many studies have demonstrated that Vitamin D has an important role in cell growth and proliferation and vitamin D receptor polymorphism has significant relationship with colorectal cancer (CRC). The aim of this study was to assess the incidence of VDR rs 2238136 polymorphism in Iranian population and to investigate the relationship between this single nucleotide polymorphism...

Dry fish is considered as a delicacy in the menu of many people Bangladesh. The most economically important marine and freshwater dried fishes are ribbon fish, bombay duck, olive barb, pomfret, shrimp, etc. In this study, fresh sample was collected from Cox's Bazar morphologically identified fish. confirmed through molecular technique using mitochondrial COI gene (cytochrome c oxidase subunit I...

Objective To assess the association between Mannose-binding lectin (MBL) gene polymorphism and susceptibility to sepsis using a meta-analysis. Methods The publications were searched on PubMed, Embase, Web of Science databases up December 1, 2019 for relevant literature. Results A total 32 studies (21 adult 11 pediatric studies) selected analysis. Overall, in three models MBL +54 A/B polymorphis...

Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current study we studied the HLA class I and class II genes in 231 Chinese voluntary b...