We present the results of a long-term HiRes spectroscopic campaign on the O-type stars in NGC 6231. We revise the spectral classification and multiplicity of these objects and we constrain fundamental properties of the O-star population. Almost three quarters of the O-type stars in the cluster are members of a binary system. The minimum binary fraction is 0.63, with half the O-type binaries hav...

Structure-based topological descriptors of chemical networks enable us the prediction physico-chemical properties and bioactivities compounds through QSAR/QSPR methods. Topological indices are numerical values to represent a graph which characterises graph. One latest distance-based index is Mostar index. In this paper, we study index, Szeged PI <math xmlns="http://www.w3.org/1998/Math/MathML" ...

The seasonal variations in the occurrence and distribution of pharmaceuticals were evaluated in seawater and sediment of Mar Menor lagoon from spring 2010 to winter 2011. A total of 20 pharmaceuticals in seawater and 14 in sediments were found at concentrations from low ngL(-)(1) up to 168ngL(-)(1) (azithromycin) in seawater and from low ngg(-1) up to 50.3ngg(-1) (xylazine) in sediments. Azithr...

Currently, there are many contaminants of concern that need to be accurately determined help assess their potential environmental hazard. Despite increasing interest, yet few occurrence data exist, likely because they present at low levels and in very complex matrices. Therefore, multiresidue analytical methods for determination highly sensitive, selective, robust. Particularly, due the trace t...

This is the supplementary material for the ICML 2013 paper Dependent Normalized Random Measures by the same authors. A. Notation & Preliminary We list some of the notation used in this paper in Table 1 for reminder. A.1. Definitions For completeness, we restate the definition of MNRM and TNRM. We are given a Poisson process on a product space R×Θ×R with intensity measure ν(dw,dθ,da) (we will us...

CRISPR/Cas9-mediated DNA cleavage (CCMDC) is becoming increasingly used for efficient genome engineering. Proto-spacer adjacent motif (PAM) adjacent to target sequence is one of the key components in the design of CCMDC strategies. It has been reported that NAG sequences are the predominant non-canonical PAM for CCMDC at the human EMX locus, but it is not clear whether it is universal at other ...

Hexavalent chromium [Cr(VI)] is a known etiological factor in human lung cancer. Cr(VI) exposure-related lung cancer has a high mutation incidence in the p53 gene. Upon intake in human cells Cr(VI) is reduced to Cr(III), which is able to conjugate with amino acids and consequently form either binary Cr(III)-DNA or ternary Cr(III)-amino acid-DNA adducts. Both binary and ternary Cr(III)-DNA adduc...

BACKGROUND Corynebacterium glutamicum is an important industrial workhorse and advanced genetic engineering tools are urgently demanded. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) have revolutionized the field of genome engineering. The CRISPR/Cas9 system that utilizes NGG as protospacer adjacent motif (PAM) and ha...

The Next Generation Grids (NGG) expert group has pioneered the vision of “Invisible Grid” whereby the complexity of Grid systems and architectures is hidden to both developers and users. In this new vision, the Grid has a different role: it will not more provide a virtual computing environment but it will be the basis of a more complex service oriented, knowledge-based and collaborative environ...