Human T-lymphotrophic virus type 1 (HTLV-1) is a retrovirus that is thought to infect approximately 10-20 million people worldwide. The majority of infected individuals remain asymptomatic carriers lifelong. HTLV-1 is thought to cause both local and systemic inflammatory diseases. The most common inflammatory condition associated with HTLV-1 is HTLV-1 associated myelopathy/Tropical spastic para...

Reaction of dialkyl acetylenedicarboxylates 1a-c andpyrrole derivatives 2a-e in the presence of triphenylphosphite (TPP) was investigated and the effect of the pyrrole substitution was established. Diastereoselectivity is observed with pyrroles, 2a,b, yieldingphosphonate ester derivatives 3a-f and 4,and their relative configuration is determined by 1H/13C and 31</...

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

A theoretical study of the kinetic and mechanism of intramoleccha cychcation of (1)-undeca-7,8-dien-2-yne was performed using MT methods at B3LYP and B3PW91 levels of theory using 6-311g, 6-311C.6-31 IGs*, 6-31I+G, 6-31 I4-SG and 6-3114H-Gs* basis seo. Equilibrium molecular geometries andharmonic vibrational frequencies of the reaccint, transition state and product wens calculated. Theconsidere...

Franc J.G.M. Klaassen, PhD (1) and Prof. Jan R. Magnus, PhD (2) 1. Department of Economics, University of Amsterdam, Roetersstraat 11, 1018 WB Amsterdam, The Netherlands. Tel: +31-205254191, Fax: +31-20-5254254. E-mail: [email protected]. 2. CentER for Economic Research, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands. Tel: +31-13-4663092, Fax: +31-134663066. E-mail: magnus@u...