BACKGROUND The diagnosis of insect venom allergy and the indication for specific immunotherapy is based on history, skin tests and demonstration of hymenoptera venom specific IgE-antibodies. In cases with contradictory test results additional cellular tests are recommended. OBJECTIVE We evaluated the usefulness of a newly introduced test based on basophil CD63 expression as marker of activati...

OBJECTIVE To investigate the risk of enzyme sensitisation and clinical allergy in workers exposed to enzymes at Novo Nordisk A/S. METHODS The study was a retrospective follow up study based on medical history and test data originally collected at routine screenings for enzyme allergy by the Occupational Health Service (OHS) of Novo Nordisk A/S during the period 1970-92. Workers were exposed t...

IgE-mediated allergic reactions have been postulated to contribute to respiratory reactions seen in workers exposed to grain dusts. In an attempt better to define the prevalence of IgE antibodies in workers exposed to grain dusts, we performed the radioallergosorbent test (RAST) on worker sera using both commercial allergens prepared from grain and worksite allergens prepared from grain dust sa...

. Egg and soy lecithins are commonly used in the food industry as emulsi®ers (E322). The possibility of residual proteins leads to suspicion of their role in allergic manifestations in subjects allergic to egg or soy. Two cases are reported in which the double-blind, placebo-controlled oral challenge (DBPCOC), the ``gold standard'' of diagnosis, led to con®rmation that lecithin had caused lesio...

BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed. OBJECTIVE To evaluate the in vitro IgE response and cross-reactivity to betalactams in patients with ...

The Department of Oto-Rhino-Laryngology, Tokyo Medical and Dental University, School of Medicine (Director: Prof. Isamu Watanabe) Although the concentration of the japanese cedar specific IgE antibody in blood can be measured with RAST, the Phadebas RAST Kit contains no japanese cedar allergen disc. Japanese cedar allergen disc (I : 20) was newly prepared. It was evaluated whether this japanese...