نتایج جستجو برای: 768 and 246
تعداد نتایج: 16828492 فیلتر نتایج به سال:
Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest Tmax of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized Cmax was observed for the dog compared to the other species. The mouse showed the highest dose-normalized AUC, which ...
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2.7. Redox Deprotections 221 3. Thiol Protecting Groups 223 4. Carboxy Protecting Groups 223 4.1. Protection 224 4.2. Deprotection 226 5. Carbonyl Protecting Groups 227 5.1. Acetals 227 5.1.1. Protection 227 5.1.2. Deprotection 231 5.2. Dithioacetals 233 5.2.1. Protection 233 5.2.2. Deprotection 235 5.3. 1,3-Oxathiolanes 237 5.4. 1,1-Diacetates (Acylals) 238 5.4.1. Protection 238 5.4.2. Deprote...
گردشگری امروزه از جمله اولین فعالیت‌ها جهت اشتغال‌زایی و درآمدزایی در جهان محسوب می‌شود در سال‌های اخیر با رشدی شتابان جایگاه ویژه‌ای پیدا کرده است. صنعت گردشگری به دلیل ماهیت چتر گونه خود دارای انواع گوناگونی است و به بخش‌های متفاوتی تقسیم می‌شود که یکی از زیر مجموعه‌های آن گردشگری کشاورزی است. یکی از مهم ترین شروط برنامه‌ریزی و توسعه گردشگری، شناسایی عوامل مؤثر بر توسعه آن است. شهرستان محلات ...
Abstract Introduction Many people wish to retain their independence as they age. Therefore, identifying factors that can predict sustainability of for older over time are essential preventing functional decline and maintaining quality life. Method Longitudinal, health, social economic data, from community-dwelling aged ≥75 years (collected at baseline (BL), 6, 12, 24 48 months), were obtained t...
Roma İmparatorluğun, kavimler göçü sonrası dağılması sonrasında Avrupa’da bir kaos ve kargaşa dönemi başlamıştır. Avrupa topraklarında Marovenj Karolenj hanedanlıklarına kadar bahsedilen süreci devam etmiştir. Şiddet, bu dönemde bütün belirgin şekilde kendisini göstermiştir. hanedanlığı ile devlet yönetim sistemi yeniden tesis edilmeye çalışılmış ancak kısa aralıklarla başarılmıştır. Charles Ma...
Although smallpox has been eradicated, the United States government considers it a "material threat" and has funded the discovery and development of potential therapeutic compounds. As reported here, the human efficacious dose for one of these compounds, ST-246, was determined using efficacy studies in nonhuman primates (NHPs), together with pharmacokinetic and pharmacodynamic analysis that pre...
Smallpox preparedness research has led to development of antiviral therapies for treatment of serious orthopoxvirus infections. Monkeypox virus is an emerging, zoonotic orthopoxvirus which can cause severe and transmissible disease in humans, generating concerns for public health. Monkeypox virus infection results in a systemic, febrile-rash illness closely resembling smallpox. Currently, there...
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