OBJECTIVES To evaluate the accuracy of B-type natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) for the diagnosis of congestive heart failure (CHF) in dyspneic patients aged >or=85 years admitted to the Emergency Department (ED), and to define threshold values in this oldest-old population. DESIGN AND METHODS This study involved 210 oldest-old patients, an...

Bacillopeptidase F (Bpr) is a fibrinolytic serine protease produced by Bacillus subtilis. Its precursor is composed of a signal peptide, an N-terminal propeptide, a catalytic domain, and a long C-terminal extension (CTE). Several active forms of Bpr have been previously reported, but little is known about the maturation of this enzyme. Here, a gene encoding a Bpr (BprL) was cloned from B. subti...

Crystals of the title compound, C(57)H(85)N(9)O(9)·CH(4)O, the methanol solvate of a nine peptide polypeptide, cyclo-(Pro-Pro-Phe-Phe-Leu-Ile-Ile-Leu-Val), were obtained after separation of the cyclic peptide from flax oil. The cyclo-linopeptide A (CLP-A) mol-ecules are linked in chains along the a axis by N-H⋯O hydrogen bonds. Each methanol O atom is hydrogen bonded to one O atom and two N-H g...

Aims There are insufficient direct comparative studies addressing the impact of type statin on their respective efficacy in heart failure (HF). The aim current study was to compare effects lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) left ventricular function, inflammatory and fibrosis biomarkers patients with chronic HF. Methods This a prospective, randomized, comparative, parallel ...

We report for the first time the immunoadjuvant effects of lipoconjugation of peptide antigens in an in vitro system by using CD4+ T-cells. The lipopeptides obtained by conjugating a palmitoyl moiety at the N(alpha)-terminal of Gln(74) or at the epsilon-NH(2) of Lys(75) of GpMBP(74-85) induced increased T-cell responsiveness compared to the native nonlipidated peptide. On the other hand, lipode...

Uses Background Concentrations Environmental Chemistry General Chemical Properties Mode of Action Fate in Soils and Water Lethal and Sublethal Effects General Terrestrial Plants and Invertebrates Aquatic Organisms Birds Mammals Recommendations Acknowledgments References Tables Number 1 Paraquat concentrations in field collections of selected organisms and nonbiological materials 2 Chemical and ...

OBJECTIVE Although serum C-peptide was previously considered biologically inactive, a growing number of recent studies have shown that it is an active peptide with important physiologic functions. The present study aimed to investigate the association of serum C-peptide level with bone mineral density (BMD) in residents of the United States. METHODS The study included 6,625 participants aged ...

Problem analysis in designing thematic maps and user interfaces which assist map designers in incorporating their ideas into maps are presented. Problems in designing choropleth maps are analyzed from the map designers point of view. A graphical user interface, called "Histogram Interface" is implemented as a countermeasure for problems in designing choropleth maps. The user interface can assis...

Claudin-3 (CLDN3) and claudin-4 (CLDN4) are the major structural molecules that form tight junctions (TJs) between epithelial cells. We found that knockdown of the expression of either CLDN3 or CLDN4 produced marked changes in the phenotype of ovarian cancer cells, including an increase in resistance to cisplatin (cDDP). The effect of CLND3 and CLDN4 on cDDP cytotoxicity, cDDP cellular accumula...