PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced PDGFR-β signaling. Interestingly and importantly, the inhibitory mechanism is distinct from the ...

Citation: Cao W, Huang H, Xia T, Liu C, Muhammad S and Sun C (2018) Homeobox a5 Promotes White Adipose Tissue Browning Through Inhibition of the Tenascin C/Toll-Like Receptor 4/Nuclear Factor Kappa B Inflammatory Signaling in Mice. Front. Immunol. 9:647. doi: 10.3389/fimmu.2018.00647 homeobox a5 Promotes White adipose Tissue Browning Through inhibition of the Tenascin c/Toll-like receptor 4/nuc...

Penicillium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively,...

Intracellular signaling in osteocytes activated by mechanical loading is important for bone formation and remodeling. These signaling events are mediated by small modulators released from Cx43 hemichannels (HC). We have recently shown that integrin a5 senses the mechanical stimulation and induces the opening of Cx43 HC; however, the underlying mechanism is unknown. Here, we show that both Cx43 ...

A method of supervaluation for Kripke's theory of truth is presented. It di ers from Kripke's own method in that it employs trees; results in a compositional semantics; assigns the intuitively correct truth values to the sentences of a particularly tricky example of Gupta's; and it is argued is acceptable as an explication of the correspondence theory of truth. In his (1982) Gupta presents the ...