ECG, electrocardiogram; CT, computed tomography; M1, acute myeloid leukemia without differentiation; WBC, white blood cells; WHO, World Health Organization; CK-MB, creatine kinase–myocardial band; CBC, complete blood count; APL, acute promyelocytic leukemia; AML, acute myelocytic leukemia; ALL, acute lymphocytic leukemia; CD, cluster of differentiation; HLA-DR, human leukocyte antigen–D related...

BACKGROUND Acute promyelocytic leukemia (APL) accounts for less than 10% of pediatric AML. Cases of APL in Down syndrome (DS) have been described in the literature rarely and it is rarer still to find the microgranular variant (M3v) of APL in trisomy 21 patients. CASE PRESENTATION We present a case of a five-year-old female with Down syndrome diagnosed with acute promyelocytic leukemia (APL)....

Absent or diminished HLA-Dr antigen representation on the cell surface of both normal and leukemic promyelocytes is a hallmark of this stage of myeloid maturation. In order to document the specificity of this finding for acute promyelocytic leukemia, flow cytometric analysis of leukemic blasts was utilized on 36 cases of acute non-lymphocytic leukemia. All 15 of the promyelocytic leukemias (FAB...

The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...

Background: Arsenic trioxide is a chemical compound that has been used as treatment for various diseases. Despite being potentially toxic, this therapy to treat Acute Myeloid Leukemia and investigated possible different types of cancer. Objectives: The present review aims describe the use studies reported in literature Trioxide therapeutic agent Leukemia, Promyelocytic Chronic Multiple Myeloma,...