the initial experience concerning the use of magnetic resonance imaging in 94 patients who had sustained chronic cord injury showed its specific advantages over traditional imaging modalities. a variety of 84 cord abnormalities were identified including myelomalacia in 47%, cord cysts in 37%, focal atrophy in 11 % and cord transection in 5%. canal stenosis was seen in twenty-five patients, elev...

Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...

Improving neurological outcome after spinal cord injury is a major clinical challenge because axons, once severed, do not regenerate but ‘dieback’ from the lesion site. Although microglia, the immunocompetent cells of the brain and spinal cord respond rapidly to spinal cord injury, their role in subsequent injury or repair remains unclear. To assess the role of microglia in spinal cord white ma...

STANDARDS There is insufficient evidence to support treatment standards. GUIDELINES There is insufficient evidence to support treatment guidelines. OPTIONS Hypotension (systolic blood pressure <90 mmHg) should be avoided if possible or corrected as soon as possible after acute spinal cord injury. Maintenance of mean arterial blood pressure at 85 to 90 mmHg for the first 7 days after acute s...

STUDY DESIGN : Literature review. OBJECTIVE : The purpose of this paper is to review clinical treatment strategies and future developments in the treatment of acute spinal cord injury. SUMMARY OF BACKGROUND DATA : The treatment of acute spinal cord injury continues to be supportive. The search for specialized pharmacologic agents to prevent secondary injury and promote repair or regeneratio...

Spinal cord injury is one of the most devastating of all traumatic conditions that can be encountered by patients. Over the past years much research has been performed on elucidating the mechanisms of spinal cord injury. Experimental and clinical studies have suggested that acute spinal cord injury is a two-step process involving primary and secondary mechanisms. Primary injury of the spinal co...

the prevalence of spinal cord injury (sci) is about 2.5 million in the worldwide and more than 130,000 new injuries reported each year. regeneration in the cns versus the pns is very different from the other tissues and many factors can prevent regeneration in pns and specially cns. previous researches demonstrated that regeneration of cns can inhibit by inhibitory molecules and glial scar. the...

spinal cord injury (sci) is a devastating condition with enormous personal and social costs. to develop preventive strategies, the determination of epidemiological features and causes is required. due to iran&apos;s high incidence of road traffic crash (rtc) injuries, epidemiologic data concerning specific causes of sci may assist in reducing this national health dilemma. in a retrospective stu...

spinal cord injuries (sci) are highly disabling and injuries. this study aims to describe the demographic and epidemiologic data on auto accident patients who were admitted at khatam alanbia hospital. the results obtained from 73 sci patients treated on the sci inpatient units of the khatam alanbia hospital (from march 2009 to march 2013) were evaluated retrospectively. then patient gender, age...