OBJECTIVES Endothelial dysfunction and alterations in heart rate variability (HRV) as well as sleep deprivation and shift work have been associated with cardiovascular disease. The aim of this study was to compare HRV and endothelial function among shift and matched non-shift workers in response to total sleep deprivation and recovery sleep under identical laboratory settings. METHODS Eleven ...

Cannabinoid type 1 (CB1) receptors are highly expressed in the brain and play a role in behavior control. Endogenous cannabinoid signaling is modulated by high-fat diet (HFD). We investigated the consequences of congenital lack of CB1 receptors on sleep in mice fed standard diet (SD) and HFD. CB1 cannabinoid receptor knock-out (KO) and wild-type (WT) mice were fed SD or HFD for 4 months (n = 9-...

STUDY OBJECTIVES Hypersynchronous delta activity (HSD) is usually described as several continuous high-voltage delta waves (> or = 150 microV) in the sleep electroencephalogram of somnambulistic patients. However, studies have yielded varied and contradictory results. The goal of the present study was to evaluate HSD over different electroencephalographic derivations during the non-rapid eye mo...

Introduction: Sleep deprivation can cause hyperalgesia and interfere with analgesic treatments. The aim of the present study was to establish an obligatory sleep-abstinence model and also evaluate the effects of intracerebroventricular (ICV) injection of crocin on pain perception in Wistar rats. Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into 5 groups ...

OBJECTIVES To investigate interindividual differences in neurobehavioral deficits during sleep deprivation, and to establish to what extent the neurobehavioral responses to sleep loss are a function of sleep history versus trait-like differential vulnerability. DESIGN Individuals were exposed to sleep deprivation on 3 separate occasions in order to determine the stability of interindividual d...

sleep deprivation is a condition of not having enough sleep it can be either chronic or acute. a chronic sleep-restricted state can cause fatigue. fatigue is a subjective state related to sleep deprivation, the more someone is deprived of sleep the more likely that person is to be fatigued. several studies indicated that drowsiness/fatigue can affect steering performance and speed control. rese...

Background: In our study, we explored anxiolytic activity of sesamol in C57BL/6 mice. Anxiety was induced mice after 72 hours sleep deprivation. assessed by three behavioural tests as Open field test, hole board test and light dark chamber test. Methods: evaluated for activity. flower pot technique, which deprivation done hours. After deprivation, the animals were subjected to tests, open Hole ...

1031 Editorial—Van Dongen Prominent discoveries in human sleep deprivation research since the turn of the millennium include (1) the cumulative, dose-response build-up of cognitive performance deficits across days of sustained sleep restriction1,2; and (2) the substantial, traitlike individual differences in vulnerability to cognitive impairment during acute total sleep deprivation (controlling...

1581 Editorial—Warby and Mongrain While it is apparent that all humans suffer decreased performance on many cognitive tasks with sleep deprivation, there is tremendous inter-individual variability in the magnitude of the impairment.1-3 The amount of impairment for each individual is specific to the type of cognitive task,1-3 and only a minor proportion of the variability is explained by baselin...

BACKGROUND Because of concerns regarding sleep deprivation, the Accreditation Council for Graduate Medical Education limits duty hours and endorses education regarding sleep loss for residents. We assessed the effectiveness of a 60- to 90-minute lecture, the Sleep, Alertness, and Fatigue Education in Residency (SAFER) program, on sleep loss and recovery sleep in residents adhering to Accreditat...