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In order to comprehend the influence of evolutionary changes in gene structure on the alternative splicing mechanism, we work on three related subjects: (i) conservation of exonintron sequences, (ii) splice site score changes and (iii) length data changes, across the vertebrate tree. We have analyzed conservation levels of human Alternative cassette exons (ACEs) ...

Alternative splicing events are classified into four main subgroups: (i) exon skipping (cassette exons), where the exon can be spliced out of the transcript together with its flanking introns; (ii) alternative 5�ss and (iii) 3�ss selection, which are the results of the recognition of two or more splice sites at one end of an exon; and (iv) intron retention, in wh...