Recovery of kidney function following an episode of acute kidney injury (AKI) is now acknowledged as a vital patient-centered outcome with clear health economic implications. In approximately 5-8% of critically ill patients with more severe forms of AKI, support with renal replacement therapy (RRT) is provided. Recent data have suggested that rates of RRT utilization in AKI are increasing. Desp...

This thesis presents a novel approach to address the challenge of planning paths for real-world multi-agent systems operating in complex environments. The technique developed, the Decentralized Multi-Agent Rapidly-exploring Random Tree (DMARRT) algorithm, is an extension of the CL-RRT algorithm to the multi-agent case, retaining its ability to plan quickly even with complex constraints. Moreove...

The prevalence of coronary artery stenosis (CAS) at the initiation of renal replacement therapy (RRT) in patients with chronic kidney disease (CKD) and no previous history of angina and/or myocardial infarction (MI) has not been fully elucidated. The prevalence of significant CAS was evaluated in 30 asymptomatic stage 5 CKD patients without a history of angina and/or MI by coronary angiography ...

Background. Hypophosphatemia in critically ill patients may be exacerbated by renal replacement therapy (RRT). We aimed to identify risk factors and adverse outcomes associated with hypophosphatemia in intensive care patients treated with RRT for acute kidney injury (AKI). Methods. This was a secondary analysis of data from a single-center prospective cohort study of medical and surgical intens...

BACKGROUND The optimal timing of renal replacement therapy (RRT) initiation for acute kidney injury (AKI) is unknown. There is debate as to whether starting RRT earlier for AKI is superior to starting it only after 'conventional', life-threatening indications are present. SUMMARY In recent years, there has been an ongoing trend in clinical practice to initiate RRT for AKI long before indicati...

BACKGROUND Myocardial infarction-related cardiogenic shock is frequently complicated by acute kidney injury. We examined the influence of acute kidney injury treated with renal replacement therapy (AKI-RRT) on risk of chronic dialysis and mortality, and assessed the role of comorbidity in patients with cardiogenic shock. METHODS In this Danish cohort study conducted during 2005-2012, we used ...

Rapidly Exploring Random Tree (RRT) is one of the quickest and the most efficient obstacle free path finding algorithm. However, it cannot guarantee finding the most optimal path.. A recently proposed extension of RRT, known as Rapidly Exploring Random Tree Star (RRT*), claims to achieve convergence towards the optimal solution but has been proven to take an infinite time to do so and with a sl...

INTRODUCTION Previous studies using Acute Kidney Injury Network (AKIN)/RIFLE criteria to classify early initiation of renal replacement therapy (RRT) have defined it as the therapy started in less severe AKIN/RIFLE stages. Generally, these studies failed in demonstrating measurable benefits. METHODS We compared RRT initiation in critically ill patients and defined early or late RRT in referen...

INTRODUCTION Acute kidney injury (AKI) is a common complication in intensive care unit (ICU) patients and is associated with increased morbidity and mortality. We compared long-term outcome and quality of life (QOL) in ICU patients with AKI treated with renal replacement therapy (RRT) with matched non-AKI-RRT patients. METHODS Over 1 year, consecutive adult ICU patients were included in a pro...