Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of tempora...

Background: Sleep Seizures (SSs) generally occur in refractory focal epilepsy, but their detailed characteristics and circadian patterns are still controversial. The effect of SSs on epilepsy surgery outcome has been addressed in few studies without definitive prognostic value.   Objectives: This study investigated the characteristics of SSs and their prognosis in refractory focal epilepsy. M...

  Background: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies.   Methods : In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sc...

the most common type of childhood-onset epilepsy syndrome is childhood absence epilepsy (cae) with well-defined electro clinical features but unknown pathological basis. the incidence of absence epilepsy is about 2 and 8 out of every 100 000 children up to the age of 16, and the prevalence is 2 and 10% of children with any form of epilepsy. children with cae suffer from high rate of pretreatmen...

Dentate granule cell neurogenesis persists throughout life in the hippocampus of mammals. Alterations in this process occur in many neurological diseases, including epilepsy. Among the different types of epilepsy, the most frequent is temporal lobe epilepsy (TLE). Therefore, a number of laboratory studies use animal models of TLE to observe the fate of neuronal cells after seizures. Hippocampal...

Epilepsy is a common outcome of traumatic brain injury (TBI), but the mechanisms of posttraumatic epileptogenesis are poorly understood. One clue is the occurrence of selective hippocampal cell death after fluid-percussion TBI in rats, consistent with the reported reduction of hippocampal volume bilaterally in humans after TBI and resembling hippocampal sclerosis, a hallmark of temporal-lobe ep...

Background/introduction Temporal lobe epilepsy (TLE) is the most common pharmacologically refractory form of epilepsy. While it can often be effectively treated by temporal lobe surgery, that does not always eliminate seizures, and many patients are not suitable candidates for surgery. A noninvasive method to augment surgical or medical treatment of TLE would be highly useful. Low-intensity foc...