Due to the emerging resistance against classical β-lactam-based antibiotics, a growing number of bacterial infections has become harder to treat. This alarming tendency necessitates continued research on novel antibacterial agents. Many classes of β-lactam antibiotics are characterized by the presence of the 3-aminoazetidin-2-one core, which resembles the natural substrate of the target penicil...

gas chromatography (gc) and gas chromatography mass spectrometry (gc-ms) were employed to determine the chemical composition of essential oil obtained from dry fruits of carum copticum. thymol (36.7%), -terpinene (36.5%) and -cymene (21.1%) were found to be the major constituents of the oil. the anti-bacterial activities of the oil were mainly investigated against food poisoning bacteria (sal...

objective: this study investigated the antibacterial properties of an ion-releasing resin composite (degufill), a hybrid resin composite (inten-s), a compomer (compoglass f) and a resin-modified glass ionomer (vitremer) against streptococcus mutans. materials and methods: the bacteria were derived from the dental plaque and cultured on blood agar plates. eppendorf tubes were filled by unset res...

background and aims. triple antibiotic paste (tap) is widely used in endodontics for root canal disinfection, particularly in regenerative procedures. the aim of this in vitro study was to evaluate the antimicrobial effects of different concentrations of tap at 1-, 2-, 3-, and 4-week intervals on mature enterococcus faecalis biofilm. materials and methods. a total of 287 extracted one-rooted hu...

echinoderms are independent and quite special branch of world animals. sea cucumbers are among the strangest members of echinoderm class regarding their structure and physiology. these fauna have been tested with regard to anti-bacterial, anti-fungal, anti-coagulants, anti-virus, cytotoxic, hemolytic and anti-hiv features. in this study, the antibacterial activity of holothuria leucospilota sea...

the edible mushrooms (basidomycetes) have high nutritional value, promote the immune system, and as a source of natural antimicrobial substances have been used to cure bacterial infections since ancient times.various kinds of proteins with several biological activities are produced by mushrooms. in this research, in order to evaluate antibacterial activity of edible mushrooms, we isolated prote...

conclusions: with respect to the obtained results and regarding to the daily increase of the resistant microbial strains to the commercial antibiotics, it can be concluded that these extracts can be proper candidates of antibacterial substance against pathogenic bacterial species especially s. aureus, e. coli, k. pneumoniae and s. epidermidis. results: the extract of c. fistula was effective ag...

A series of potent antibacterial agents have been prepared. These agents are penems carrying a lactone ring in the C-2 position. Excellent activity against Gram-positive and Gram-negative organisms--except Pseudomonas aeruginosa--was found.

Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.