Multifunctional nanoplatforms based onmesoporous silica nanoparticles (MSNs) have recently shown great promise in drug delivery and therapy. Herein, a multifunctional nanoplatform based on MSNs is fabricated by a modified micro-emulsion method for drug delivery and imaging-guided chemo/photodynamic synergistic therapy. Carbon dots (C-dots) and a photosensitizer, rose bengal (RB), are embedded i...

introduction: considering the importance of prevention in periodontal diseases and the important role of aggregatibacter actinomycetemcomitans in induction and progression of these diseases, the aim of the present in vitro study was to compare the antimicrobial effects of chlorhexidine digluconate (chx), curcumin and light-emitting diode (led) laser, on this bacterium. methods: antimicrobial ac...

Photodynamic therapy (PDT), also known as photoradiation therapy, phototherapy, or photochemo therapy, involves the use of a photoactive dye (photosensitizer) that is activated by exposure to light of a specific wavelength in the presence of oxygen. The transfer of energy from the activated photosensitizer to available oxygen results in the formation of toxic oxygen species, such as singlet oxy...

Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promote alternate technologies that may be more affective than current antibiotics. This article reviews Photodynamic Antimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visible light illumination and found to be effective against most types of mic...

background: antimicrobial effi cacy of photodynamic therapy (pdt) depends on both the photosensitizer (ps) and laser parameters. in the present study, antimicrobial effectiveness of pdt with different concentrations of two pss was compared. materials and methods: in this study, we employed fi fty-nine 6-week-old male wistar rats. all except the negative and overall control groups were immunosup...