Piper chaba Hunter, a flowering vine of Piperaceae family, has been using for long time in south Asian country for culinary meat preparation. As stem and root of this plant has been using traditionally in fat rich meat preparation, the antioxidant and anticoagulation potential of this herb is a great interest of study and it was evaluated using cold and boiled water extract of dried and grinded...

BACKGROUND & AIMS The pathogenesis of irritable bowel syndrome (IBS) remains only partially understood, and no specific or universally effective patient management procedure has been developed to date. Our study was designed to evaluate if colonic luminal serine-proteases may be a relevant pathophysiologic marker of IBS. METHODS Fecal samples of 38 IBS patients, 15 patients with ulcerative co...

Serum mannose-binding protein (MBP) is a C-type lectin that binds to terminal mannose and N-acetylglucosamine moieties present on surfaces of certain pathogens and activates the classical complement pathway. In the present study, we describe the mechanism underlying the activation triggered by MBP. The human serum MBP fraction was obtained by sequential affinity chromatography on mannan-Sepharo...

Matriptase is a type II transmembrane serine protease. In the present study, matriptase C-terminal fragments containing the catalytic serine protease domain were found to occur on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells transfected with a cDNA encoding the protease. This suggests that matriptase interacts with various potential substrates when expressed in...