background polyvinyl alcohol (pva) is one of the well-known polymers, which has been used in numerous biomedical applications because of its good biocompatibility. objectives due to problems made by the therapeutics already used for leishmaniasis, the aim of this study was to evaluate the effect of pva containing artemether in treating cutaneous leishmaniasis in balb/c mice. materials and metho...

Delayed-type hypersensitivity reaction measured by skin testing, is an important tool for evaluation of cellular immune response in leishmaniasis and has been used recently as an indication of exposure to infection. Skin testing in leishmania infection needs a standard reagent with high specificity, sen‌sitivity, and potency. In the present work, a soluble leishmanin, and three whole parasite p...

the aim of this study was to prepare a new formula of leishmania major (l. major) crude antigen and evaluate its effect on immune system. for this purpose l. major promastigotes were cultured, harvested, washed, and resuspended in physiologic saline and the suspensions were dispersed in five equal batches. 0.1 ml of various doses of the cocktail antigen were injected intradermaly in three group...

background: cutaneous leishmaniasis (cl) is one of the most important neglected tropical diseases and a major public health challenge in iran caused by leishmania spp and transmitted by phlebotomine sand flies. the number of cl cases has shown an increasing pattern all over the country, including the district of varamin, southeast of tehran, iran. this study aimed to identify the leishmania spp...

three species of l. tropica, l. major and l. infantum are known as main causal agents of leishmaniasis have been reported in iran. since cutaneous leishmaniasis (cl) is endemic in north east of iran, in the present work, 50 leishmania positive isolates from human cases in mashhad (center of razavi province, north east of iran), were genotyped by means of polymerase chain reaction-restriction fr...

background: leishmaniasis, especially cutaneous leishmaniasis, is considered an important health problem in many parts of iran including kharve, khorasan razavi province. cutaneous leishmaniasis is caused by various species of leishmania, each having a different secondary host. thus, identifying the parasites’ specie is of paramount importance for containment strategy planning. the morphologica...

conclusions l. major is the main species responsible for cutaneous leishmsniasis in four geographical regions of khuzestan province southwestern of iran and nested pcr can be used for diagnosis and leishmania species identification. results 138 (94.5%) out of 146 cases of four regions were l. major and 8(5.5%) were l. tropica. 57.97% of l. major cases were male and 42.03% were female. 87.5% of ...

delayed-type hypersensitivity reaction measured by skin testing, is an important tool for evaluation of cellular immune response in leishmaniasis and has been used recently as an indication of exposure to infection. skin testing in leishmania infection needs a standard reagent with high specificity, sen sitivity, and potency. in the present work, a soluble leishmanin, and three whole parasite p...

abstract          background and objective: cutaneous leishmaniasis is a parasitic disease and a health problem in different parts of iran, especially two cities of mashhad and chabahar. due to morphological similarities of most leishmania species and difference in reservoirs of l. major and l. tropica, it is necessary to determine the parasite specie to combat the disease. thus, this study use...