Regarding registration and publication of clinical trials, there are now three registry organizations in Japan; the University Hospital Medical Information Network (UMIN), the Japan Pharmaceutical Information Center (JAPIC) and the Japan Medical Association - Center for Clinical Trials (JMACCT). In addition, a portal site which supports searching for information on clinical trials in all three ...

An experimentally supported model of cortical background activity is used to investigate the role of such activity in neural gain control. The model demonstrates the feasibility of a scheme for contrast enhancement where by the overall intensity of an input pattern adjusts the dynamic range of a neuron such that it remains sensitive to contrast over a wide range of overall intensities. keywords...

Several signal subspace techniques have been recently suggested for the extraction of the visual evoked potential signals from brain background colored noise. The majority of these techniques assume the background noise as white, and for colored noise, it is suggested to be whitened, without further elaboration on how this might be done. In this paper, we investigate the whitening capabilities ...

Previously we reported that correlations between the activities of peripheral afferents mediate a phase invariant representation of natural communication stimuli that is refined across successive processing stages thereby leading to perception and behavior in the weakly electric fish Apteronotus leptorhynchus (Metzen et al., 2016). Here, we explore how phase invariant coding and perception of n...

The aim of this study was to investigate the spectral characteristics of Purkinje cell interspike background activity caused by the occurrence of particular action potentials or by electrically induced enhancement of cerebellar inhibitory and excitatory input drive. Spontaneously active Purkinje neurons were extracellularly recorded in anesthetized rats before and after cessation of stimulation...

Phase slip and beat phenomena are ubiquitous in many forms of wave superposition. Likewise, it is trivially true that cumulative summation of white noise gives rise to “brown noise” (1/f power spectrum). We assume that the background electrocorticogram (ECoG) to a first approximation results from integration of innumerable action potentials by dendrites. This paper presents a simulation that re...

images were scanned using a Hewlett Packard 6300 dpi resolution scanner. The MeP footprint of androgen receptor cooperatively bound to DNA revealed for the first time guanines that became hypersensitive to DMS methylation (Figure 1). Since DMS normally methylates guanines uniformly, the hypermethylation of guanine indicates local distortion to the DNA. Therefore, MeP is an ideal footprinting m...

To reconstruct synaptic background activity, we combined computational models with intracellular recordings in vivo. A new conductance analysis method applied to intracellular recordings in the somatosensory cortex of anesthetized rats revealed mirror changes of excitation and inhibition during the upand down-states of slow waves, but concerted changes in conductance variances. We then used the...

Introduction: This study aims to investigate the influence of background activity variation on image quantification in differently reconstructed PET/CT images. Methods: Measurements were performed on a Discovery-690 PET/CT scanner using a custom-built NEMA-like phantom. A background activity level of 5.3 and 2.6 kBq/ml 18F-FDG were applied. Ima...

Clonal emergence of group A streptococci (GAS) with reduced susceptibility to fluoroquinolones (FQs) has been increasingly reported. Non-susceptibility is associated with various point mutations in the target-encoding genes and has only been described in a few emm types. We used a well-characterised GAS clinical paediatric collection from Brussels (Belgium) and Brasília (Brazil) to analyse the ...