نتایج جستجو برای: bax expression
تعداد نتایج: 877301 فیلتر نتایج به سال:
Introduction: The amount of expression of BAX and BCL-2 genes in infertile men’s sperm as well as its association with sperm parameters and DNA fragmentation index is an issue which has not been studied yet. In this research, it is assumed that up-regulation of BAX and downregulation of BCL-2 are directly associated with sperm DNA fragmentation. Methods: After obtaining semen samples from the ...
Introduction: Regular exercise training with alternating volume fluctuatesblood glucous levels and by regulating signaling in gene expression reduces in myocardial cell apoptosis in diabetic patients. The purpose of this study was the effect of 8 weeks of high intensity interval training on the gene expression of BAX and BCL-2 in the left ventricle of diabetic rats. Methods: The present study ...
objective: curcumin, is the active component in turmeric (curcuma long). this agent induces apoptosis via inhibiting various signaling pathways. however, its poor aqueous solubility prevents its widespread application. in this study, dendrosomes with water-solubility, nano-sized dimensions and nontoxic properties, was used for curcumin delivery to cells. materials & methods: in the present...
Background & Objective: To study the immunophenotype of prostate cancer (PC) with the presence and absence of intraluminal inclusions (IIn), depending on the grade score. Methods: A total of 30 PC samples with IIn (group E) and 30 PC samples without them (group C) were studied. These groups were divided into 2 subgroups, depending on the grade of malignan...
Radiotherapy plays an important role in the treatment of hepatocellular carcinoma (HCC). Cyclin G1 is a novel member cyclin family, and it abnormally expressed HCC. In this study we investigated radiotherapy HCC cells. The expression was silenced by transfection G1-siRNA into HepG2 cells Huh7 cells, mRNA protein measured qRT-PCR Western blot analysis. proliferation analyzed using MTT assay, rad...
The objective of this study was to evaluate the apoptotic effects of increasing granulosa cell density and increasing estradiol on relative gene expression associated with apoptosis factors (Bcl-2, Bax and GADD45β) and cell cycle (CCDN-2). For this reason after collecting ovaries of cows from an abattoir, granulosa cells were separated from 4- to 8-mm follicles. Then, viable cells were counted ...
Currently, it has been suggested that human mesenchymal stem cells (MSCs), a well-known multipotent cells, could modify the biological process in leukemia cells. Therefore, we evaluated MSCs’ possible effects on apoptosis and proliferation of acute lymphoblastic (ALL) MOLT-4 Accordingly, were co-cultured with MSCs. Then, 24, 48, 72 hours after treatment, percentages cell was estimated using flo...
Background and Objectives: Researches have shown that progesterone influences the viability of breast cancer cells. The purpose of this study was to investigate the effect of progesterone on the viability of MCF-7 cell line and evaluation of Expression level of P53, Bax, and Bcl-2 Genes. Methods: In this laboratory-experimental study, MCF-7 cells were purchased from Pasture institute and div...
background: nowadays, oocytes and embryos vitrification has become a routine technique. based on clinical judgment, re-vitrification maybe required. but little is known about re-vitrification impact on genes expression. objective: the impact of re-vitrification on apoptotic and implanting genes, bax, bcl-2 and erbb4, at compaction stage embryos were evaluated in this study. materials and method...
objective: breast cancer is the second leading cause of cancer death in women. cisplatin is a traditional cancer drug commonly used in chemotherapy for killing cancer cells. modulation at the mrna levels of apoptotic related genes often correlate with the sensitivity of various types of cancer cells to chemotherapeutic agents. nanoparticulate drug delivery systems are being developed to effecti...
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