Individuals with bipolar disorder are at increased risk for suicide attempts and completion. Although anxiety may be a modifiable suicide risk factor among bipolar patients, anxiety disorder comorbidity has not been highlighted as critical in identification of high-risk individuals nor has its treatment been integrated into suicide prevention strategies. In this study, ancillary to the Systemat...

Affective temperaments are considered to be antecedents or sub-syndromal manifestations of bipolar disorders. It is, however, unknown how these temperaments develop into bipolar disorders. We hypothesize that: [1] just before the onset of bipolar disorder, the left medial frontal gyrus (MFG) of cyclothymic and/or hyperthymic healthy subjects may degenerate and shrink in volume concomitantly wit...

The current renewed interest in the field of bipolar disorders can be attributed to various factors which are reviewed in this Special Section of the International Journal of Neuropsychopharmacology. Bipolar disorders are one of the most frequent disorders in psychiatry and this Special Section presents papers on recent advances in the clinical course, epidemiology, biological models and neurob...

BACKGROUND Affective temperaments are presumed to underlie bipolar psychopathology. The TEMPS-A has been widely used to assess affective temperaments in clinical and non-clinical samples. Cross-sectional research supports the association of affective temperaments and mood psychopathology; however, longitudinal research examining risk for the development of bipolar disorders is lacking. The pres...

Editorial A few weeks ago, after many years of intensive work, the much-awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was published. It is still the case today that psychiatric diagnoses seem to be more consensus-based than validity-based (Cuthbert and Insel 2013; Bschor et al. 2012; Berk 2013) something that DSM-5 will also be unable to change. In s...

ôbjective: the mood disorder questionnaire (mdq) has been designed as a screening self-report inventory for diagnosing bipolar mood disorders. this study investigated the validity and the optimal cut-off threshold of the persian version of mdq in a group of ïranian depressive patients. methods: ône hundred and twenty patients with probable diagnosis of mood disorders attending psychiatric clini...

Abstract Introduction: Psychiatric disorders such as bipolar disorder and schizophrenia cause vascular, neurological, and neurobiological changes. On other hand, salivary glands are influenced by changes in the autonomic nervous system. Therefore, this  hypothesis was formed that psychiatric disorders can affect salivary glands through neurological pathways. This study aimed to evaluate if sc...

OBJECTIVE Comorbid anxiety disorder is reported to increase suicidality in bipolar disorder. However, studies of the impact of anxiety disorders on suicidal behavior in mood disorders have shown mixed results. The presence of personality disorders, often comorbid with anxiety and bipolar disorders, may explain these inconsistencies. This study examined the impact of comorbid Cluster B personali...

Accurate diagnosis of mood disorders is critical for treatment to be effective. Distinguishing between major depression and bipolar disorders, especially the depressed phase of a bipolar disorder, is essential, because they differ substantially in their genetics, clinical course, outcomes, prognosis, and treatment. In current practice, bipolar disorders, especially bipolar II disorder, are unde...