Shear stress is known to have a significant effect on the state of cellular differentiation. It also induces morphologic responses including changes to cytoskeletal organization subsequently leading to changes in cell shape. In fact, fluid shear stress caused by blood flow is a major determinant of vascular remodeling and can lead to development of atherosclerosis. The morphological changes are...

The persistence of shear stress fluctuations in viscous liquids is a direct consequence of the non-zero shear stress of the local potential minima which couples stress relaxation to transitions between inherent structures. In simulations of 2D and 3D glass forming mixtures, we calculate the distribution of this inherent shear stress and demonstrate that the variance is independent of temperatur...

A volume-penalizing immersed boundary method is presented that facilitates the computation of incompressible fluid flow in complex flow domains. We apply this method to simulate the flow in cerebral aneurysms, and focus on the accuracy with which the flow field and the corresponding shear stress field are computed. The method is applied to laminar, incompressible flow in curved cylindrical vess...

This paper describes the conditions for initiation and maintenance of secondary currents in open channel flows. By analyzing the Reynolds equation in the wall-normal and wall-tangent directions, this study reveals that, like other types of vortices, the secondary currents are originated in the near-boundary region, and the magnitude (or strength) of secondary flow is proportional to the lateral...

The fluctuating bed shear stress has largely been investigated only for the conditions of uniform channel flows and boundary layers. In practical engineering, the flow conditions are often modified due to the presence of various hydraulic structures. To what extent the modification affects the known characteristics of the bed shear stress is not clear. This study presents experimental results o...

With the assumption that the bed shear stress fluctuates in a lognormal fashion, the probability density function (pdf) of the standardised bed shear stress is derived as a function of the relative shear stress intensity. The pdf is more skewed with larger relative intensities, but approaches a Gaussian function when the relative intensity is small. The computed pdf agrees well with the reporte...

We consider a variant of the classical ‘Rayleigh problem’ (‘Stokes’s first problem’) in which a semi-infinite region of initially quiescent fluid is mobilised by a shear stress applied suddenly to its boundary. We show that self-similar solutions for the fluid velocity are available for any generalised Newtonian fluid, regardless of its constitutive law. We demonstrate how these solutions may b...

A three-dimensional computer model of human aortic arch with three branches is reproduced to study the pulsatile blood flow with Finite Element Method. In specific, the focus is on variation of wall shear stress, which plays an important role in the localization and development of atherosclerotic plaques. Pulsatile pressure pulse is used as boundary condition to avoid flow entry development, an...

We used computer simulations to study spontaneous strain localization in granular materials, as a result of symmetry breaking non-homogeneous deformations. Axisymmetric triaxial shear tests were simulated by means of standard three-dimensional Distinct Element Method (DEM) with spherical grains. Carefully prepared dense specimens were compressed between two platens and, in order to mimic the ex...

In this paper, a displacement-based, variationally consistent, two variable refined theory for shear deformable beams is presented. The beam is assumed to be of linearly elastic, homogeneous, isotropic material and has a uniform rectangular cross-section. In this theory, the beam axial displacement and beam transverse displacement consist of bending components and shearing components. The assum...