A 54-year-old woman with a known history of multifocal hepatocellular carcinoma was treated with selective internal radiation therapy (SIRT) using yttrium-90 ((90)Y) microspheres, despite disease relapses after surgical resection and transarterial chemoembolization. She developed a dramatic clinical, radiological and metabolic response after 9 weeks. This case provides visual illustration of th...

OBJECTIVE To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases. DATA SOURCES Published studies and scientific paper presentations. STUDY SELECTION Randomized clinical studies and retrospective reviews. CONCLUSIONS S...

nano-hydroxyapatite/gelatin (nha/ge) microspheres are currently used in bone tissue engineering as bone filler. in this  study, the effect of fabrication process parameters on the particle size of nano-hydroxyapatite/gelatinmicrospheres was investigated. the nha/ge microspheres were fabricated using water in oil emulsion. in order to design an experimental design, a surface response model with ...

       The cellular therapy and nerve tissue engineering will probably become a major therapeutic strategy for promoting axonal growth through injured area in central nervous system and peripheral nervous system in the coming years. The stem cell carrier scaffolds in nerve tissue engineering resulted in strong survival of cells and suitable differentiation into n...

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

Partial breast irradiation (PBI) by either brachytherapy or external beam (EB) therapy is frequently used for the treatment of certain populations of breast cancer patients. The claim that brachytherapy is better than EB for PBI is the Proposition debated here. Advantages claimed for brachytherapy for PBI include: • brachytherapy is associated with smaller treatment volumes, lower integral dose...

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

(90)Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres is a radiopharmaceutical product that is comprised of (90)Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres production the capabilit...

SCIENTIFIC BACKGROUND Percutaneous transluminal angioplasties (PTA) through balloon dilatation with or without stenting, i.e. vessel expansion through balloons with or without of implantation of small tubes, called stents, are used in the treatment of peripheral artery occlusive disease (PAOD). The intravascular vessel irradiation, called intravascular brachytherapy, promises a reduction in the...