Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...

Role of Lipids in the Development of Brain Infarction: The Framingham Study • An association of blood lipids with the development of atherothrombotic brain infarction under age 60 is demonstrated. This is based on 18 years' surveillance of 5,209 men and women, of whom 52 men and 59 women developed brain infarction. The relationship under age 60 was statistically significant only for men. Trigly...

Background: The cerebellum is the most important portion of the brain, which audits our acts and establishes balance. Symptoms from a cerebellar stroke happen suddenly. In addition to specific cerebellar signs and symptoms, other common symptoms of a cerebral stroke include dizziness, headache, nausea, vomiting, double vision, tremor, and vertigo. These symptoms can be confused with other situa...

Stroke is the third most common cause of mortality and the leading cause of disability in the United States. There are about 700,000 new cases each year with ischemic brain infarction accounting for almost 85% of all strokes. In this issue of CNS Spectrums, new and potential treatments for acute ischemic stroke and the cognitive changes that often result are discussed. There are approximately 3...

Background and Purpose We investigated the changes of circadian blood pressure patterns after thromboembolic and hemodynamic brain infarction and evaluated the relation between circadian blood pressure variation, infarct location, and activation of the autonomic nervous system after thromboembolic stroke. Methods Repeated 24-hour blood pressure measurements were performed in 45 patients with pr...

It remains unclear whether or not the infarcted brain caused by aortic dissection should be reperfused when an emergency operation is needed for aortic arch dissection. A 64-year-old woman presented with severe back pain and syncope with a sudden left hemiplegia. CT scan demonstrated an aortic dissection of the entire aorta, obstruction of the right common carotid artery by extended aortic diss...

background: the role of renin angiotensin system (ras) in ischemic/reperfusion (i/r) injuries is not fully elucidated. furthermore, it is not clear whether inhibition of ras by angiotensin-converting enzyme (ace) inhibitors has beneficial effects in terms of protecting the brain from i/r injuries. in this study enalapril is used as an ace inhibitor to evaluate the role of ras in i/r injuries in...

Forty-nine children with complicated bacterial meningitis were studied. Thirteen had abnormalities on computed tomography compatible with the diagnosis of brain infarction; one had a brain biopsy with the histological appearance of infarction. Factors exist in childhood bacterial meningitis which are associated with the development of brain infraction.