this review deals with studies that have used cdna microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. the key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. it concludes that “basal-like” carcinomas d...

  Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on...

objective: n-nitroso-n-methylurea (nmu) induces breast cancer in rodents, particularly in rats. this model of breast cancer is very similar to human breast cancer. as a continuation of our recent work, we investigated the expressions of cyclin d1 and p21 in nmu-induced breast cancer of wistar albino rats. materials and methods: in this experimental study, mammary carcinoma was induced in female...

Background: Pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. Breast cancer is one of the most common cancers among women worldwide. Treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

Primary Adenoid Cystic Carcinoma of Breast (bACC) is an extremely rare salivary gland like tumor accounting for less than 0.1% all breast tumors with excellent prognosis. These are generally triple negative. There limited data on optimal treatment and management.

although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue. sarcomas represent less than 1% of primary breast neoplasms. these tumors are at high risk of recurrence and are known to have poor prognosis. surgical resection is the primary treatment for these lesions and axillary lymph node dissection is not r...

introduction: the gastrin releasing peptide (grp) receptor is over expressed in a variety of common human tumors. radiolabeled bombesin analogues have exhibited high binding affinity for these receptors. the aim of this study was to assess the value of a new 99mtc-bombesin analog in the differentiation of malignant from benign breast tumors. methods: 99mtc-bombesin scans were performed in 21 pa...

background: preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. on the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage iiia breast cancer without preoperative therapy. methods: we retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemothe...

while carcinoma of breast is common condition, stromal sarcomas are rare tumors of breast, amongst which fibrosarcoma accounts for 16% of cases. only a few case reports are available in the international literature. we report a case of fibrosarcoma of breast, which presented as an un-encapsulated mass in the right breast of a 60-year-old female. this case was diagnosed after exclusion of all po...