Background: TP53 and the oncogene WRAP53 are adjoining genes, producing p53-WRAP53α sense-antisense RNA couples. WRAP53α is indispensable for p53 mRNA regulation and p53 induction following DNA damage. Up-regulated WRAP53β can induce neoplastic transformation and cancer cell survival. All these, along with the associations of WRAP53 single nu...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

background : the incidence of thyroid cancer has varied from 2 per 100,000 in europe to 21 per 100,000 in the hawaiian chinese population and is 2-3 fold more common in females. middle east cancer consortium figures from 1996-2001 have recorded different age standardized incidence rates that ranged from 2 per 100,000 in egypt to 7.5 per 100,000 among israeli jews. in jordan the age standardized...

this study was undertaken to define the epidemiological aspects of thyroid carcinoma in iran, an area of endemic iodine deficiency nearly until recently. the tehran cancer institute data system registry (tcidsr) was used to identify patients with different histological types of thyroid cancer (tc) in iran. data were analyzed from 438 thyroid cancer cases identified by the tcidsr in 1998-99. dis...

Background: Breast cancer is one of the most common diseases in women and causes more deaths rather than other cancers. The increasing trend of breast cancer in Iran makes clear the need of extensive breast cancer research in this area. Some studies showed that in the variety countries and even in the different areas in one country has different risk of breast cancer incidence and this is a rea...

Ovine pulmonary adenocarcinoma (OPA) is a contagious and transmissible lung cancer of sheepresembling human bronchiolo-alveolar carcinoma. In the present study, lungs of 9400 sheep slaughtered inFars province, Iran were examined morphopathologically. The OPA was diagnosed in the lungs of 21(0.22%) out of 9400 sheep. Frequency of involvement of different lobes in the affected lungs was includeda...

background: is the third cause of death. the present study aimed at providing the incidence rates (crude and agestandardized)of different types of cancers in sistan and baluchestan province (southeastern of iran).cancer is the second leading cause of death in developing countries. in iran, cancermethodsregistry center of health heputy for sistan and baluchestan province. common cancers weredefi...

background: we examined epidemiological aspects of dynamic changes in incidence of ovarian cancer in women of kazakh and russian nationalities in kazakhstan. methods: the material of investigation was primary data on registered patients with malignant ovarian tumors in the whole country. the study was conducted during the period of 1999-2009. evaluation of changes in ovarian cancer incidence in...

esophageal cancer is the second most common malignancy in iranian men; it is the third in women. it is killing about 5800 iranians each year. squamous cell carcinoma (scc) is presently the most common type of esophageal cancer accounting for about 90% of all esophageal cancers in iran. recent studies in iran have shown that there is a gradual increase in the incidence of adenocarcinoma of the d...