BACKGROUND To investigate the expression of chemokine ligand 2 (CCL2), chemokine ligand 18 (CCL18), and vascular endothelial growth factor (VEGF) in peripheral blood of patients with gastric cancer and their correlation with presence of malignancy and disease progression. METHODS Sixty patients with pathological proved gastric cancer were prospectively included into study. The levels of CCL2,...

BACKGROUND AND AIM SP-D, YKL-40, CCL18 and CA 15-3 are pulmonary markers that have been extensively investigated in different chronic pulmonary diseases. However, in acute pulmonary diseases, such as community-acquired pneumonia (CAP), little is known about the course of these markers and their relationship with the aetiological agent. The aim of this study was to investigate the course of thes...

The purpose of the present study was to investigate the effects of upregulating microRNA (miR)-181b expression in tumor-associated macrophages regarding breast cancer cell metastasis and to identify the target gene. Ectopic miR-181b was transfected into MDA-MB-231 and MCF-7 breast cancer cell lines with or without chemokine ligand 18 (CCL18) stimulation. Cell proliferation, migration/invasion a...

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. We aimed to investigate complex spatial and neighboring characteristics of AD skin. performed Visium transcriptomics sequencing in biopsies from 6 healthy control (HC) donors 7 patients (lesion non lesion). For single-cell analysis, we analyzed previously published data suction blister material full-thickness (4 ADs 5 ...

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration ...

BACKGROUND AND OBJECTIVE Bronchiolitis obliterans organizing pneumonia (BOOP) is a distinct clinicopathological entity histologically characterized by intra-alveolar granulation tissue and absence of extensive fibrotic lesions. Effective macrolide treatment of BOOP has been reported anecdotally. This study aimed to investigate whether alveolar macrophages (AMs) produce aberrant proinflammatory ...

BACKGROUND CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. METHODS We measured CCL3-5-18 serum concentrations in 712 patients with chest ...

The management of pauci–immune focal necrotizing GN (FNGN) remains a challenge, with morbidity and mortality remaining stubbornly high. Well powered controlled clinical trials have optimized older treatments and introduced new ones, but substantial numbers of those affected still die of active disease or from the toxicity of the drugs used to treat it.1,2 Current strategies for tailoring therap...