نتایج جستجو برای: ccl18

تعداد نتایج: 245  

2013
Sabina A. Islam Morris F. Ling John Leung Wayne G. Shreffler Andrew D. Luster

The CC chemokine ligand 18 (CCL18) is one of the most highly expressed chemokines in human chronic inflammatory diseases. An appreciation of the role of CCL18 in these diseases has been hampered by the lack of an identified chemokine receptor. We report that the human chemokine receptor CCR8 is a CCL18 receptor. CCL18 induced chemotaxis and calcium flux of human CCR8-transfected cells. CCL18 bo...

Journal: :Arthritis and rheumatism 2007
Antje Prasse Dmitri V Pechkovsky Galen B Toews Markus Schäfer Stephan Eggeling Corinna Ludwig Martin Germann Florian Kollert Gernot Zissel Joachim Müller-Quernheim

OBJECTIVE In diffuse parenchymal lung diseases, the evolution of pulmonary fibrosis is often devastating and may result in death. In this study the role of CCL18 as a biomarker of disease activity in idiopathic interstitial pneumonias (IIPs) and systemic sclerosis (SSc) with lung involvement was evaluated. METHODS CCL18 was assessed in supernatants of cultured bronchoalveolar lavage (BAL) cel...

Journal: :The European respiratory journal 2014
Andreas Hector Carolin Kröner Melanie Carevic Martina Bakele Nikolaus Rieber Joachim Riethmüller Matthias Griese Gernot Zissel Dominik Hartl

Cystic fibrosis (CF) lung disease is characterised by chronic Pseudomonas aeruginosa infection and leukocyte infiltration. Chemokines recruit leukocytes to sites of infection. Gene expression analysis identified the chemokine CCL18 as upregulated in CF leukocytes. We hypothesised that CCL18 characterises infection and inflammation in patients with CF lung disease. Therefore, we quantified CCL18...

2014
Guo Chen Yu-xiang Liang Jian-guo Zhu Xin Fu Yan-fei Chen Ru-jun Mo Liang Zhou Hao Fu Xue-cheng Bi Hui-chan He Sheng-bang Yang Yong-ding Wu Fu-neng Jiang Wei-de Zhong

BACKGROUND AND AIM CC chemokine ligand 18 (CCL18) promotes malignant behaviors of various human cancer types. However, its involvement in human prostate cancer has not been fully elucidated. The aim of this study was to investigate the role of CCL18 in PCa. METHODS Expression of CCL18 at mRNA and protein levels was detected using real-time qRT-PCR and immunohistochemistry analysis. We analyze...

Journal: :Biochimica et biophysica acta 2006
Mariëlle J van Breemen Boris Bleijlevens Chris G de Koster Johannes M F G Aerts

SELDI-TOF MS assisted the discovery of the chemokine CCL18/PARC as plasma biomarker for pathological storage cells in Gaucher disease patients. Prognostic elevation of CCL18 in blood of Gaucher patients has been confirmed by ELISA. Given its low molecular mass, positive charge, and relatively high abundance, CCL18 seems a particular attractive protein for SELDI-TOF based quantitation. Therefore...

Journal: :Journal of immunology 2004
Andor Pivarcsi Michael Gombert Marie-Caroline Dieu-Nosjean Antti Lauerma Robert Kubitza Stephan Meller Juliane Rieker Anja Muller Ludivine Da Cunha Anna Haahtela Eniko Sonkoly Wolf-Herman Fridman Harri Alenius Lajos Kemeny Thomas Ruzicka Albert Zlotnik Bernhard Homey

Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression...

2012
Irina G Luzina Sergei P Atamas

CCL18, a chemokine with no known receptor, has been implicated in several fibrotic pulmonary diseases associated with T-lymphocyte infiltration. It has been hypothesized that CCL18 may act through CCR6. Gene delivery of human CCL18 to the lungs of wild-type mice induced pulmonary infiltration of T-lymphocytes, less than 5% of which expressed CCR6. In the lungs of CCR6-deficient mice, CCL18-driv...

2016
Canhua Jiang Dan Yang Jie Wang

This study aims to investigate the expression and clinical significance of CC chemokine ligand 18 (CCL18) in the serum and tumor tissue of the patients with oral squamous cell carcinoma (OSCC). Enzyme linked immunosorbent assay (ELISA) was used to detect the serum CCL18 contents in 59 patients with OSCC and 17 healthy adults; immunohistochemistry was used to detect the CCL18 expressions in 97 s...

2016
Qi Wang Yong Tang Hongjing Yu Qiaoyun Yin Mengdi Li Lijun Shi Wei Zhang Danrong Li Li Li

CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up-regulated in ovarian carcinoma compared with adjacent tissue an...

Journal: :Arthritis Research & Therapy 2007
Judith Auer Markus Bläss Hendrik Schulze-Koops Stefan Russwurm Thomas Nagel Joachim R Kalden Martin Röllinghoff Horst Ulrich Beuscher

Rheumatoid arthritis (RA) is characterized by the recruitment of leukocytes and the accumulation of inflammatory mediators within the synovial compartment. Release of the chemokine CCL18 has been widely attributed to antigen-presenting cells, including macrophages and dendritic cells. This study investigates the production of CCL18 in polymorphonuclear neutrophils (PMN), the predominant cell ty...

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