In recent years, size of VLSI circuits is dramatically grown and layout generation of current circuits has become a dominant task in design flow. Standard cell placement is an effective stage of physical design and quality of placement affects directly on the performance, power consumption and signal immunity of design. Placement can be performed analytically or heuristically. Analytical placer...

Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...

In this paper the parametric study is carried out to investigate the effect of number of cells in optimal cost of the non-prismatic reinforced concrete (RC) box girder bridges. The variables are geometry of cross section, tapered length, concrete strength and reinforcement of the box girders and slabs that are obtained using ECBO metaheuristic algorithm. The design is based on AASHTO standard s...

This paper reviews recent strategies used for increasing specific yield and productivity in high cell density cultures. High cell density cultures offer an efficient means for the economical production of recombinant proteins. However, there are still some challenges associated with high cell density cultivation (HCDC) techniques. A variety of strategies in several aspects including host design...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

Cell formation problem in Cellular Manufacturing System (CMS) design has derived the attention of researchers for more than three decades. However, use of sequence data for cell formation has been the least investigated area. Sequence data provides valuable information about the flow patterns of various jobs in a manufacturing system. This paper presents a new mathematical model to solve a cell...

background and objective: microbial protein production can resolve one of the major world challenges, i.e. lack of protein sources. candida tropicalis growth was investigated to specify a medium to reach the highest cell proliferation and protein production. material and methods: fractional factorial design and the index of signal to noise ratio were applied for optimization of microbial protei...

design and optimization of a single crystalline silicon (c-si) solar cell is performed to achieve the maximum light conversion efficiency. various parameters such as doping concentration and thicknesses, and geometrical dimension of surface pyramids are studied. the inverted surface pyramid is used to increase the efficiency of the solar cell, and engineered oxide layer is used as the passivati...