Langerhans cells (LC) are skin-resident antigen-presenting that regulate immune responses to epithelial commensal and pathogenic microorganisms. Infection of skin by human papillomavirus (HPV) is commonly persistant can promote malignant transformation. As LCs considered important in control HPV infection, we compared the transcriptome from transformed oncogenic E7 protein HPV16 healthy skin. W...

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Immunotherapy is a rapidly developing field of multiple myeloma, disease which despite the development new drugs remains incurable. There are several antigens that being assessed in preclinical and clinical settings, but most studied all B-cell maturation antigen (BCMA). BCMA target for antibody conjugated with toxins (ADCs), bispecific engagers (BITEs), modified autologous lymphocytes (CAR-T, ...

allergic rhinitis  (ar) is  an  inflammatory  disorder  of  the  nasal  mucosa  with  high morbidity and prevalence. natural killer (nk) cells might have a role in ar. we aimed to evaluate the changes of the markers and receptors on nk cells in ar patients compared to the non-atopic controls. flow  cytometric  analysis was  used  with  double  staining  of  the  peripheral  blood mononuclear ce...

Newly generated T cells are unable to respond to antigen/MHC. Rather, post-selection single-positive thymocytes must undergo T cell maturation to gain functional competency and enter the long-lived naive peripheral T cell pool. This process is poorly understood, as no gene specifically required for T cell maturation has been identified. Here, we demonstrate that loss of the transcriptional repr...

objective: dendritic cells (dcs) are the most effective antigen-presenting cells with many applications. however, dcs can be generated in vitro by various methods from bone marrow cells, each with varying pros and cons. thus, we evaluated three different methods to generate dcs from mice bone marrow cells. materials and methods: bm cells from c57bl/6 mice were cultured in the presence of 1000 u...

The membrane form of immunoglobulins (mIg) is expressed on the surface of B lymphocytes from a very early developmental stage in the bone marrow (pre B cell) until the cell finally differentiates into a plasma cell. mIgs associate with other transmembrane proteins to form the B cell antigen receptor complex (BCR). Numerous studies have confirmed that signaling through the BCR not only steers th...