discussions in comparison to the control of wy14643, sandoz58-035, c9 and t11-cla, epa increased the pparα mrna levels (p = 0.024, p = 0.041, p = 0.043, and p = 0.004, respectively), even though, la had no significant effect on the pparα mrna expression (p = 0.489). materials and methods this experimental study investigated the effects of c9, t11-conjugated linoleic acid (c9, t11-cla). alpha li...

The protective effect of a L-type calcium channel blocker, nimodipine, on cell injury induced by oxygen-glucose deprivation (OGD) in PC12 cells was investigated. PC12 cells were exposed to in-vitro oxygen-glucose deprivation (30 minutes and 60 minutes respectively) in the presence or absence of nimodipine (10mM/L) in three different time schedules (pre-24h, pre-3h and concurrently). Cellular vi...

Shark cartilage is considered as a natural dietary supplement consisting of anti-angiogenic, immunostimulatory, and anti-inflammatory characteristics. Therefore, this study was designed to inspect the possibility that whitecheek shark (Carcharhinus dussumieri) cartilage proteins motivate expression of NKG2D, CXCR3, NKP46, and NKP44 receptors on natural killer cells and their activities against ...

A mediator (synaptic transmitter, neurotransmitter) is a physiologically active substance found in nerve cell bound form, which secreted from an excited ending into the synaptic cleft and specifically acts on receptors of postsynaptic target [1].

Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification...

Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet routine use or able to achieve insulin independence patients. In addition this, the principles of T1D treatment remain essentially unchanged since isolation insulin, almost a century ago. is characterized by deficiency as result destruction insulin-producing beta cells mediated...

Tuberculosis (TB) is a chronic infectious disease mainly caused by Mycobacterium tuberculosis (M. tuberculosis). The structures of polysaccharides and glycolipids at M. cell wall vary among different strains, which affect the physiology pathogenesis mycobacteria activating or inhibiting innate acquired immunity. Among them, some components such as lipomannan (LM) lipoarabinomannan (LAM) activat...

stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. it has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...