Chemotherapy (chemo) is the specific systematic treatment administered in oncological practice for malignant neoplasms in order to destroy chaotically dividing abnormal cells. Chemo is a part of anticancer treatment along with radiotherapy, immunotherapy and surgery. The drugs used in chemotherapeutic protocols cannot be purchased over the counter; they can be taken with prescription only. Canc...

About 10% of apparently normal individuals are sensitive to clastogenic effects of physico-chemical agents. More than 45% of breast cancer patients’ exhibit elevated radiosensitivity. Although the nature of inherent radiosensitivity is not fully understood, but insufficiency and impaired DNA repair mechanism might be prime cause of radiosensitivity. This is evident from genetically affect...

Abstract AIMS To collect prospective, real- time data and lived experiences to determine if the chemo-radiotherapy pre- treatment information materials we provide our patients need be updated. METHOD A repeat cross-sectional, qualitative design was followed whereby individuals were interviewed at specific points. These defined as prior radiotherapy (following planning scan mould room); during r...

esophageal squamous cell carcinoma is a rather common cancer in northern iran. incidence of adenocarcinoma of esophagus has an increasing trend in iran. co-existence of both cancers in one patient is very rare. we report a middle age woman from northern iran with a typical presentation of esophageal cancer, who was found to have a dual esophageal cancer. the disease was found in the advanced st...

The relevance of an uncompromised immune system for the development and progress of breast cancer still is a matter of intensive research. The impact of chemo- and/or radiotherapy on peripheral blood immune cell counts and activity of breast cancer patients (n=660) was investigated by flow cytometry. Not only the absolute counts, but also the comparison of those counts with standard values were...

BACKGROUND To investigate the feasibility and efficacy of salvage lung resection and describe the possible indications and contraindications in patients with primary lung cancer. METHODS Thirty patients undergoing anatomical salvage lung resection were classified into three groups: GI, patients with progressive lung tumor despite definitive chemo- and/or radiotherapy; GII, patients who underw...

OBJECTIVE The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings. METHODS Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied retrospectively. RESU...

BACKGROUND Endometrial cancer is a common female malignancy. Patients with high-risk endometrial cancer have relatively high incidence of metastasis and recurrence. Despite complete resection, patients with stage III or IV are at high risk of local or distant recurrence. Systemic adjuvant treatment includes chemotherapy and radiotherapy. But the optimal scheduling is not known. Recently propose...

BACKGROUND Rectal squamous cell carcinoma (SCC) is a rare tumor. The incidence of this malignancy has been reported to be 0.25 to 1 per 1000 colorectal carcinomas. From a review of the English literature 55 cases of SCC of the rectum have been published. In this study we report a rectal metastatic SCC to the liver, discussing the efficacy of aggressive adjuvant and neo-adjuvant therapies on sur...

Gastric and colorectal cancers (GC and CRC) have poor prognosis and are resistant to chemo- and/or radiotherapy. In the present study, the prophylactic effects of dendritic cell (DC) vaccination are evaluated on disease progression and clinical benefits in a group of 54 GC and CRC patients treated with DC immunotherapy combined with cytokine-induced killer (CIK) cells after surgery with or with...