Background & Objective:  Toxico-pathological effects of herbal plants have always been a major concern, but little information is provided on the toxico-pathological effects of origanum on the fetus. Due to ethical rules and regulations, no drug experiment on the human fetus is permitted; hence, the chick embryo model is used as an ideal opportunity to study the adverse effects of drugs. This ...

   Background: In this feasibility study, a mechanically loaded in-vitro tissue culture model of joint morphogenesis using the isolated lower extremity of the 8 day old chick embryo was developed to assess the effects of mechanical loading on joint morphogenesis. Methods: The developed in-vitro system allows controlled flexion and extension of the chick embryonic knee with a range of motion of ...

The chick embryo – past, present and future as a model system in developmental biology 1011 PART I: The chick as a classical system for the study of development L. Wolpert (UK) Much more from the chicken's egg than breakfast – a wonderful model system 1015 C. Tickle (UK) The contribution of chicken embryology to the understanding of vertebrate limb development 1019 L. Wittler, M. Kessel (German...

Expression of the Nodal gene, which encodes a member of the TGFbeta superfamily of secreted factors, localizes to the left side of the developing embryo in all vertebrates examined so far. This asymmetric pattern correlates with normal development of the left-right axis. We now show that the Wnt and PKA signaling pathways control left-right determination in the chick embryo through Nodal. A Wnt...

1. The changes in the net amounts of retinol, retinyl esters and retinal in both the developing chick embryo and the newly hatched chick were investigated. The embryo requires about 68nmol of the vitamin for its growth, whereas the baby chick requires about 108nmol during the first 7 days after hatching. 2. Retinal was present in the egg in fairly high concentrations at the beginning of the inc...

Ott (1, 2) has shown that desoxypyridoxine (2,4-dimethyl-3-hydroxy5hydroxymethylpyridine) and methoxypyridoxine (2-methyl-3-hydroxy4-methoxymethyl-5-hydroxymethylpyridine), analogues of pyridoxine, act as pyridoxine antagonists in the chick. Because of our interest in the effects of metabolic antagonists on the development of the chick embryo (3), and on the behavior of mouse tumors growing on ...

In ovo studies on the effect of 1,3,5, ppm Bioneem (0.03%) formulation on Biochemical aspect of chick embryo revealed that there was dose dependent total protein reduction in 96 hrs old embryo (treated at 24 hrs) as compared to the control. Also there was reduction in total protein concentration Liver, Brain and Heart of 15 day old chick embryo (treated with Bioneem at 96 hrs. stage) as compare...

Fertilized chicken eggs are suggested as an alternative to mammalian models. The chorioallantoic membrane (CAM) of the chick embryo is widely used for examination of angiogenesis, xenotransplants and for virus production. Unfortunately, it is mostly not taken into account, that the chick embryo's ability to experience pain starts to develop at day 7 of breeding. In our view, this model is only ...