Ion exchange resins have versatile properties as drug delivery vehicles and have been extensively studied in the development of novel drug delivery systems1. Cation exchange resins containing strong sulfonic acid group form a strong bond with cationic drugs and elution of drug from resinates is slower2. Formulations based on ion exchange resins are successfully marketed viz Pennkinetic system b...

OBJECTIVE The objective of this study is to review the main investigations into the secondary effects of the antihistamine chlorpheniramine on the central nervous system (CNS). DEVELOPMENT The antagonists of the H1 receptors of histamine, usually used in the treatment of symptoms of allergy or the common cold, have many adverse effects on the CNS. They cause day time drowsiness, cause poorer ...

OBJECTIVE(S) The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain. MATERIAL AND METHODS Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inflammatory ...

In 12 asthmatic (A) and ten normal (N) subjects, we measured the effect of inhaled saline solution, acetylcholine, histamine (H), and chlorpheniramine (CP) on specific airway conductance and forced exploratory flows. We found that CP dilated the bronchi in six asthmatic patients and one normal subject by acting on bronchial H1 receptor. This action is also modulated by the abnormal functions of...

It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorom...

the role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of chlorpheniramine as histamine h1-receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male ross broiler chicks reared in groups of four weeks, 16 samples (control and test) were then in...

Purpose: To synthesize a new series of 1-substituted-4-(pyridin-4-yl) [1,2,4] triazolo[4,3-a]quinazolin5(4H)-ones and evaluate them for H1-antihistaminic activity with negligible side effects in guinea pigs. Methods: The synthesized compounds were characterized by Infrared spectroscopy (IR), proton nuclear magnetic resonance (H-NMR) and mass spectrometry (MS) data. The purity of the compounds w...

A series of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4] triazolo[4,3-a]quinazolin-5-ones (4a-j) were synthesized by the cyclization of 3-(3-ethylphenyl)-2-hydrazino-3H-quinazolin-4-one (3) with various one-carbon donors. The starting material, compound 3, was synthesized from 3-ethyl aniline by a new innovative route with improved yield. When tested for their in vivo H1-antihistaminic acti...