AIM The aim of this study was to determine the incidence of TNBC in Kuwait, to analyze the clinicopathologic features and prognosis of this type of breast cancer, and compare it with reports from other regions of the world. BACKGROUND Triple negative breast cancer (TNBC) is defined as a subtype that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor re...

BACKGROUND A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. METHODS Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification...

Result: The total number of hysterectomy specimens received was 179. The patient's age ranged between 23-90 years with an average age of 49 years old. The most common clinical indication for hysterectomy was present and previous malignancies 50 (27.9%) including cases of therapeutic and follow up hysterectomies for gynecologic malignancies followed by uterine leiomyoma 44 (24.5%). Other clinica...

BACKGROUND To clarify the biologic behavior of the early signet-ring cell cancers (SRCs) by comparing the clinicopathologic features and the incidence of lymph node metastasis between different histologic types of early gastric cancer (EGC) and to propose the indications of endoscopic surgery for SRCs. METHODS Clinicopathologic features and the incidence of lymph node metastasis of 422 EGCs w...

BACKGROUND The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF). METHODS We retrospectively selected and reviewed the clinicop...