Fibrillar collagens are the more abundant extracellular proteins. They form a metazoan-specific family, and are highly conserved from sponge to human. Their structural and physiological properties have been successfully used in the food, cosmetic, and pharmaceutical industries. On the other hand, the increase of jellyfish has led us to consider this marine animal as a natural product for food a...

BACKGROUND Collagens of marine origin are applied increasingly as alternatives to mammalian collagens in tissue engineering. The aim of the present study was to develop a biphasic scaffold from exclusively marine collagens supporting both osteogenic and chondrogenic differentiation and to find a suitable setup for in vitro chondrogenic and osteogenic differentiation of human mesenchymal stroma ...

Is collagen just the workhorse of the extracellular matrix with few roles other than merely giving the body structural platforms? Hardly so. The collagen family has now swelled to at least 27 distinct members and thus is full of promise for functional diversity (1). Granted, some collagens belong to the best known and most abundant structural proteins. However, collagens also control sophistica...

A simple method has been developed for the isolation of Acid Soluble Collagen (ASC) and Pepsin Digestible Collagen (PDC) from the skin of Albacore tuna (Thunnus alalunga), Dog shark (Scoliodon sorrakowah), and one among Indian Major Carps ie, Rohu (Labeo rohita). Biochemical characterization of the collagen extracted was carried out. On wet weight basis the yields of ASC and PDC from shark skin...

Fibroblasts are essential for tissue repair due to producing collagens, and lysosomal proteinase cathepsin B (CatB) is involved in promoting chronic inflammation. We herein report that CatB regulates the expression of collagens III and IV by fibroblasts in response to a TLR2 agonist, lipopolysaccharide from Porphyromonas gingivalis (P.g. LPS). In cultured human BJ fibroblasts, mRNA expression o...

The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified so far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, baseme...