Visualizing a complex network is computationally intensive process and depends heavily on the number of components in the network. One way to solve this problem is not to render the network in real time. PRE-render Content Using Tiles (PRECUT) is a process to convert any complex network into a pre-rendered network. Tiles are generated from pre-rendered images at different zoom levels, and navig...

The findings of the COMBINE Study have recently been published (Anton et al 2006). The COMBINE Study is a major, multisite RCT of acamprosate and naltrexone in conjunction with behavioural treatment. As such this study has the potential to significantly influence treatment of alcohol dependence. This brief critical appraisal of the COMBINE Study has been prepared to assess its implications in t...

The COMBINE Project analyses opportunities and problems provided by the Traffic Management System (TMS) when using the moving block signalling system for railway operation. The site chosen for verification is the Breda triangle in the Dutch part of the high-speed line Paris-Brussels-Amsterdam. Currently, there are no applications of moving block on main-line railways, apart from several test in...

Comparative molecular binding energy analysis (COMBINE) [1] is a helpful approach for estimation of binding affinity of congeneric ligands that bind to a common receptor. The essence of COMBINE is that the ligand-receptor interaction energies are decomposed into residue-based energy contributions, and then the partial least squares (PLS) analysis is applied to correlate energy features with bio...

The primary goal of the OPTIMA project is to optimize HVAC systems (heating, ventilation and air conditioning systems) and building structures with respect to energy consumption. Presently the focus is developing an integrated computerized system for simulation purposes. A central data repository defined by a data model provides data persistency. The existing data models developed in ATLAS [1,2...