The commonly used drug diclofenac is an important environmental anthropogenic pollutant. Currently, detection of diclofenac is mainly based on chemical and physical methods. Here we describe a yeast biosensor that drives the diclofenac-dependent expression of a recombinant fluorescent protein from the authentic promoter of the PDR5 gene. This key component of the pleiotropic drug response encod...

background: aflatoxin contamination of food and feed stuff is a serious health problem and significant economic concerns. in the present study, the inhibitory effect of candida parapsilosis ip1698 on mycelial growth and aflatoxin production in aflatoxigenic strains of aspergillus species was investigated. methods: mycelial growth inhibitions of nine strains of aflatoxigenic and non-aflatoxigeni...

Background: The aim of this study was to compare the effectiveness of methadone detoxification with traditional method of gradual decrement in the abused amount of the refined opium dross (Shireh) to control withdrawal syndrome in Shireh-addicted patients. Methods: In this study, two groups of Shireh addicts were compared. The first group was treated by methadone and the second group by gr...

Background: Addiction as a biopsychosocial problem has been dramatically increased in our country. Adverse consequences of the addiction in women have been shown to be more than men, which in turn can affect family members’ health and wellbeing. The current study examined the efficacy of stress coping skills training in addicted women referring to an outpatient centre of addiction prevention lo...

background: the aim of this study was to compare the effectiveness of methadone detoxification with traditional method of gradual decrement in the abused amount of the refined opium dross (shireh) to control withdrawal syndrome in shireh-addicted patients. methods: in this study, two groups of shireh addicts were compared. the first group was treated by methadone and the second group by gradual...

Cyclophosphamide (CP) is a commonly used antineoplastic agent despite its adverse effects. Hemorrhagic cystitis (HC)is one of the most common side effects CP. Although Mesna to prevent HC, it suffers from few sideeffects. Therefore, search for better alternate substance still continues. In this study, we studied ursolic acid(UA), active ingredients Plantago major, called plantain or white man’s...

Cancer treatments can often adversely affect the quality of life young women. One most relevant negative impacts is loss fertility. Cyclophosphamide one detrimental chemotherapeutic drugs for ovary. may induce destruction dormant follicles while promoting follicle activation and growth. Herein, we demonstrate in vivo protective effect allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on si...

introduction: cyclophosphamide is a chemotherapy drug with several side effects on various organs such as male reproductive system that can cause infertility. in this study, we assessed combined effect of ginger and pumpkin extractson rat testis after cp injection. methods: forty adult male rats were randomly divided into 4 groups: the control group received intraperitoneal injection of isotoni...