BACKGROUND In the present study, antidepressant-like activity of palmatine was evaluated in unstressed and stressed young male Swiss albino mice. METHODS The animals were subjected to unpredictable mild stress daily for 21 successive days to induce depression-like behavior. Palmatine (0.25, 0.5, 1 mg/kg, ip) was administered for 21 successive days to unstressed and stressed mice. The antidepr...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...

Introduction: Depression is a widely prevalent form of mental illnesses worldwide. It commonly associated with sad mood, loss interest or pleasure, feelings guilt low self-worth, disturbed sleep appetite, and energy. Mimosa pudica has many medicinal properties, are used in traditional medicine the treatment various medical conditions. This study was conducted to better understand antidepressant...

The role of the opioid system in mediating effects of alcoholism and stress in depression is far from clear. We studied, therefore, the effects of chronic mild stress (CMS) and alcohol drinking on depression-like behavior and nociception in lines of mice selected for high (HA) or low (LA) swim stress-induced analgesia. Compared to the LA mice, the HA animals display up-regulation of opioid rece...

Animal models of depression are used to study pathophysiology of depression and to advance therapeutic strategies. Stress-induced depression models in rodents are widely used. However, amenable behavioral criteria and experimental procedures that are suitable for animal models have not been established. Given that depression is clinically diagnosed by multiple symptomatic criteria and stress ef...

background: the present study investigated the effects of gallic acid (ga) administration on trimethyltin chloride (tmt) induced anxiety, depression, and hippocampal neurodegeneration in rats. materials and methods: in this experimental study, the rats received intraperitoneal (i.p.) injections of tmt (8 mg/kg). the animals received either ga (50, 100 and 150 mg/kg) or saline as the vehicle for...

Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

Argyreia speciosa (Convolvulaceae) is regarded as a ‘Rasayan’ drug in the Ayurveda system of medicine to cure diseases of the nervous system. This work researched the action of the hydroalcoholic extract of A. speciosa root (ASE) on experimentally-induced anxiety, depression and convulsion in rodents. ASE (100, 200, 500 mg/kg, p.o.) was tested for the elevated plus maze, open field, forced swim...

BACKGROUND The neurobiological changes underlying depression resistant to treatments remain poorly understood, and failure to respond to selective serotonin reuptake inhibitors may result from abnormalities of neurotransmitter systems that excite serotonergic neurons, such as histamine. METHODS Using behavioral (tail suspension test) and neurochemical (in vivo microdialysis, Western-blot anal...